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Helq Gene Detail
Summary
  • Symbol
    Helq
  • Name
    helicase, POLQ-like
  • Synonyms
    D430018E21Rik, Hel308
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176740
    NCBI Gene: 191578
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100910011-100946464 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.52 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176740
 protein coding gene Chr5:100910010-100946529 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029791
 protein coding gene Chr5:102272512-102309954 (-)
A/J MGP_AJ_G0029757
 protein coding gene Chr5:98458689-98495898 (-)
AKR/J MGP_AKRJ_G0029703
 protein coding gene Chr5:101698053-101734532 (-)
BALB/cJ MGP_BALBcJ_G0029767
 protein coding gene Chr5:99484871-99521341 (-)
C3H/HeJ MGP_C3HHeJ_G0029490
 protein coding gene Chr5:102045668-102083386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030222
 protein coding gene Chr5:106519642-106557232 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027457
 protein coding gene Chr5:93699431-93738681 (-)
CAST/EiJ MGP_CASTEiJ_G0028901
 protein coding gene Chr5:100711321-100748885 (-)
CBA/J MGP_CBAJ_G0029460
 protein coding gene Chr5:110216056-110254795 (-)
DBA/2J MGP_DBA2J_G0029604
 protein coding gene Chr5:98647589-98684756 (-)
FVB/NJ MGP_FVBNJ_G0029563
 protein coding gene Chr5:97450832-97487344 (-)
LP/J MGP_LPJ_G0029692
 protein coding gene Chr5:102885464-102921900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029592
 protein coding gene Chr5:115276091-115313469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030255
 protein coding gene Chr5:101180790-101217823 (-)
PWK/PhJ MGP_PWKPhJ_G0028619
 protein coding gene Chr5:97083746-97120252 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028454
 protein coding gene Chr5:98853146-98889616 (-)
WSB/EiJ MGP_WSBEiJ_G0028979
 protein coding gene Chr5:101516131-101553689 (-)



Homology
more
  • Human Ortholog
    HELQ, helicase, POLQ like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HELQ, helicase, POLQ like
  • Synonyms
    HEL308
  • Links
    NCBI Gene ID: 113510
    neXtProt AC: NX_Q8TDG4
    UniProt: Q8TDG4

  • Chr Location
    4q21.23; chr4:83407343-83455883 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced fertility and increased incident of tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035266 Ensembl Gene Model | MGI Sequence Detail 36454 C57BL/6J ±  kb
    transcript ENSMUST00000044684 Ensembl | MGI Sequence Detail 3689 Not Applicable  
    polypeptide ENSMUSP00000041599 Ensembl | MGI Sequence Detail 1069 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141056, MGI:2443481
    References
    more
    • Summaries
      All 43
      Diseases 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:347863 Bakhshalizadeh S, et al., A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model. Genes (Basel). 2024 Mar 4;15(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory