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Pla2g15 Gene Detail
Summary
  • Symbol
    Pla2g15
  • Name
    phospholipase A2, group XV
  • Synonyms
    C87498, LLPL, Lpla2, Lypla3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178076
    NCBI Gene: 192654
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106877031-106891347 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178076
 protein coding gene Chr8:106876986-106891350 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034077
 protein coding gene Chr8:108497640-108511948 (+)
A/J MGP_AJ_G0034058
 protein coding gene Chr8:104159084-104173598 (+)
AKR/J MGP_AKRJ_G0033984
 protein coding gene Chr8:107169523-107183830 (+)
BALB/cJ MGP_BALBcJ_G0034051
 protein coding gene Chr8:104340887-104355235 (+)
C3H/HeJ MGP_C3HHeJ_G0033763
 protein coding gene Chr8:107906656-107921525 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034571
 protein coding gene Chr8:112476368-112490722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031513
 protein coding gene Chr8:97288294-97303962 (+)
CAST/EiJ MGP_CASTEiJ_G0033089
 protein coding gene Chr8:107433207-107447583 (+)
CBA/J MGP_CBAJ_G0033736
 protein coding gene Chr8:116088444-116103830 (+)
DBA/2J MGP_DBA2J_G0033891
 protein coding gene Chr8:103494733-103509040 (+)
FVB/NJ MGP_FVBNJ_G0033836
 protein coding gene Chr8:102428587-102442789 (+)
LP/J MGP_LPJ_G0033982
 protein coding gene Chr8:108707485-108721781 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033880
 protein coding gene Chr8:119273955-119288904 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034589
 protein coding gene Chr8:107135291-107149647 (+)
PWK/PhJ MGP_PWKPhJ_G0032790
 protein coding gene Chr8:102909462-102924666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032631
 protein coding gene Chr8:105831001-105847858 (+)
WSB/EiJ MGP_WSBEiJ_G0033205
 protein coding gene Chr8:107822526-107836977 (+)



Homology
more
  • Human Ortholog
    PLA2G15, phospholipase A2 group XV
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G15, phospholipase A2 group XV
  • Synonyms
    ACS, GXVPLA2, LLPL, LPLA2, LYPLA3
  • Links
    NCBI Gene ID: 23659
    neXtProt AC: NX_Q8NCC3
    UniProt: Q8NCC3

  • Chr Location
    16q22.1; chr16:68245304-68261058 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice do not develop atherosclerotic lesions even when fed an atherogenic diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    103
  • cDNA Data
    76
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031903 Ensembl Gene Model | MGI Sequence Detail 14317 C57BL/6J ±  kb
    transcript ENSMUST00000034377 Ensembl | MGI Sequence Detail 2706 Not Applicable  
    polypeptide ENSMUSP00000034377 Ensembl | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 76
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142884
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 17
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:261411 Danyukova T, et al., Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Hum Mol Genet. 2018 May 15;27(10):1711-1722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory