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Usp7 Gene Detail
Summary
  • Symbol
    Usp7
  • Name
    ubiquitin specific peptidase 7
  • Synonyms
    2210010O09Rik, Hausp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182061
    NCBI Gene: 252870
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:8506586-8574931 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 4.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182061
 protein coding gene Chr16:8506586-8610172 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022499
 protein coding gene Chr16:5361883-5470815 (-)
A/J MGP_AJ_G0022461
 protein coding gene Chr16:5045892-5150001 (-)
AKR/J MGP_AKRJ_G0022437
 protein coding gene Chr16:5323771-5433924 (-)
BALB/cJ MGP_BALBcJ_G0022465
 protein coding gene Chr16:5215205-5321418 (-)
C3H/HeJ MGP_C3HHeJ_G0022232
 protein coding gene Chr16:5361984-5475136 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022914
 protein coding gene Chr16:5507622-5625713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020435
 protein coding gene Chr16:5243578-5349903 (-)
CAST/EiJ MGP_CASTEiJ_G0021759
 protein coding gene Chr16:5381189-5497014 (-)
CBA/J MGP_CBAJ_G0022201
 protein coding gene Chr16:5717127-5832421 (-)
DBA/2J MGP_DBA2J_G0022332
 protein coding gene Chr16:5091525-5197847 (-)
FVB/NJ MGP_FVBNJ_G0022308
 protein coding gene Chr16:5074971-5179286 (-)
LP/J MGP_LPJ_G0022400
 protein coding gene Chr16:5333505-5442016 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022330
 protein coding gene Chr16:5505876-5618492 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022927
 protein coding gene Chr16:5273904-5379453 (-)
PWK/PhJ MGP_PWKPhJ_G0021499
 protein coding gene Chr16:5263744-5369403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021329
 protein coding gene Chr16:5328147-5429940 (-)
WSB/EiJ MGP_WSBEiJ_G0021807
 protein coding gene Chr16:5307770-5422314 (-)



Homology
more
  • Human Ortholog
    USP7, ubiquitin specific peptidase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP7, ubiquitin specific peptidase 7
  • Synonyms
    C16DELp13.2, DEL16P13.2, HAFOUS, HAUSP, TEF1
  • Links
    NCBI Gene ID: 7874
    neXtProt AC: NX_Q93009
    UniProt: Q93009

  • Chr Location
    16p13.2; chr16:8892097-8975328 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic growth arrest and die between E6.5 and E7.5. Mice homozygous for a conditional allele activated in neural cells exhibit complete neonatal lethality, absent gastric milk, uncoordinated movement and abnormalforebrain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    13
  • cDNA Data
    16
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252870 NCBI Gene Model | MGI Sequence Detail 68346 C57BL/6J ±  kb
    transcript NM_001003918 RefSeq | MGI Sequence Detail 5427 C57BL/6  
    polypeptide Q6A4J8 UniProt | EBI | MGI Sequence Detail 1103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000017196 ubiquitin carboxyl-terminal hydrolase 7
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR002083 MATH/TRAF domain
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR008974 TRAF-like
      IPR024729 Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
      IPR029346 Ubiquitin carboxyl-terminal hydrolase, C-terminal
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    • GlyGen
      Q6A4J8 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917314, MGI:2146342, MGI:2146361, MGI:2146552, MGI:2146656, MGI:2146709
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 11
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:346442 Migale R, et al., FOXL2 interaction with different binding partners regulates the dynamics of ovarian development. Sci Adv. 2024 Mar 22;10(12):eadl0788
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory