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Sgk3 Gene Detail
Summary
  • Symbol
    Sgk3
  • Name
    serum/glucocorticoid regulated kinase 3
  • Synonyms
    2510015P22Rik, A330005P07Rik, Cisk, cytokine-independent survival kinase, fy, Sgkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182368
    NCBI Gene: 170755
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:9868332-9971070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 2.08 cM
  • Mapping Data
    53 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182368
 protein coding gene Chr1:9868332-9972795 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015828
 protein coding gene Chr1:7043345-7157870 (+)
A/J MGP_AJ_G0015810
 protein coding gene Chr1:7113954-7219251 (+)
AKR/J MGP_AKRJ_G0015769
 protein coding gene Chr1:6997808-7102109 (+)
BALB/cJ MGP_BALBcJ_G0015766
 protein coding gene Chr1:6846652-6952927 (+)
C3H/HeJ MGP_C3HHeJ_G0015600
 protein coding gene Chr1:6912414-7020941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016220
 protein coding gene Chr1:7386857-7500544 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013941
 protein coding gene Chr1:5944259-6052283 (+)
CAST/EiJ MGP_CASTEiJ_G0015180
 protein coding gene Chr1:7104031-7221873 (+)
CBA/J MGP_CBAJ_G0015573
 protein coding gene Chr1:7523096-7647260 (+)
DBA/2J MGP_DBA2J_G0015672
 protein coding gene Chr1:6733423-6836615 (+)
FVB/NJ MGP_FVBNJ_G0015677
 protein coding gene Chr1:6646249-6750940 (+)
LP/J MGP_LPJ_G0015744
 protein coding gene Chr1:7265918-7375376 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015696
 protein coding gene Chr1:8203681-8318554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016266
 protein coding gene Chr1:6898159-7004662 (+)
PWK/PhJ MGP_PWKPhJ_G0014964
 protein coding gene Chr1:6594314-6703608 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014744
 protein coding gene Chr1:7055820-7171691 (+)
WSB/EiJ MGP_WSBEiJ_G0015244
 protein coding gene Chr1:6926233-7036330 (+)



Homology
more
  • Human Ortholog
    C8orf44-SGK3, C8orf44-SGK3 readthrough
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C8orf44-SGK3, C8orf44-SGK3 readthrough
  • Links
    NCBI Gene ID: 100533105
    neXtProt AC: NX_Q96BR1
    UniProt: Q96BR1

  • Chr Location
    chr8:66667596-66862022 (+)  GRCh38
  • Human Ortholog
    SGK3, serum/glucocorticoid regulated kinase family member 3
  • Synonyms
    CISK, SGK2, SGKL
  • Links
    NCBI Gene ID: 23678
    neXtProt AC: NX_Q96BR1
    UniProt: Q96BR1

  • Chr Location
    8q13.1; chr8:66712734-66862022 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 10 alleles in 10 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in wavy vibrissae and coat/hair anomalies due to impaired hair follicle development and/or hair cycle defects. Homozygotes for a null allele show increased food intake and fecal K+ excretion and reduced intestinal glucose transport and fasting plasma glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    101
  • cDNA Data
    65
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025915 Ensembl Gene Model | MGI Sequence Detail 102739 C57BL/6J ±  kb
    transcript ENSMUST00000097826 Ensembl | MGI Sequence Detail 2728 Not Applicable  
    polypeptide ENSMUSP00000095437 Ensembl | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 68
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9908, MGD-MRK-9910, MGI:1919672, MGI:2443375, MGI:95603
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 35
    • Earliest
      J:90 DICKIE MM, et al., Fuzzy mice. J Hered. 1950 Jul;41(7):193-6
    • Latest
      J:328943 Sun J, et al., CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3beta/beta-catenin pathway. Front Cardiovasc Med. 2022;9:970745
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory