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Grhl1 Gene Detail
Summary
  • Symbol
    Grhl1
  • Name
    grainyhead like transcription factor 1
  • Synonyms
    LBP-32, p61 MGR, p70 MGR, Tcfcp2l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182540
    NCBI Gene: 195733
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:24622282-24667390 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182540
 protein coding gene Chr12:24622234-24667390 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019629
 protein coding gene Chr12:22250362-22298258 (+)
A/J MGP_AJ_G0019596
 protein coding gene Chr12:21645115-21690316 (+)
AKR/J MGP_AKRJ_G0019567
 protein coding gene Chr12:22375589-22420617 (+)
BALB/cJ MGP_BALBcJ_G0019573
 protein coding gene Chr12:21914734-21960154 (+)
C3H/HeJ MGP_C3HHeJ_G0019377
 protein coding gene Chr12:22255241-22300383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020021
 protein coding gene Chr12:22935708-22980602 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017645
 protein coding gene Chr12:21127934-21172280 (+)
CAST/EiJ MGP_CASTEiJ_G0018932
 protein coding gene Chr12:17200980-17248155 (+)
CBA/J MGP_CBAJ_G0019348
 protein coding gene Chr12:23662649-23713134 (+)
DBA/2J MGP_DBA2J_G0019462
 protein coding gene Chr12:21497811-21542834 (+)
FVB/NJ MGP_FVBNJ_G0019453
 protein coding gene Chr12:21388129-21434122 (+)
LP/J MGP_LPJ_G0019532
 protein coding gene Chr12:22319566-22365891 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019488
 protein coding gene Chr12:23535129-23581824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020060
 protein coding gene Chr12:21932290-21980058 (+)
PWK/PhJ MGP_PWKPhJ_G0018699
 protein coding gene Chr12:16225109-16271211 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018487
 protein coding gene Chr12:16436056-16480966 (+)
WSB/EiJ MGP_WSBEiJ_G0018983
 protein coding gene Chr12:22088220-22134327 (+)



Homology
more
  • Human Ortholog
    GRHL1, grainyhead like transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRHL1, grainyhead like transcription factor 1
  • Synonyms
    LBP32, MGR, NH32, TFCP2L2
  • Links
    NCBI Gene ID: 29841
    neXtProt AC: NX_Q9NZI5
    UniProt: Q9NZI5

  • Chr Location
    2p25.1; chr2:9951693-10002277 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display alopecia or sparse hair, abnormal hair follicle root sheaths, thickening of the cornified layer on the paws, and postnatal growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1025
  • Tissues
    201
  • cDNA Data
    63
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020656 Ensembl Gene Model | MGI Sequence Detail 45109 C57BL/6J ±  kb
    transcript ENSMUST00000085553 Ensembl | MGI Sequence Detail 3469 Not Applicable  
    polypeptide ENSMUSP00000082689 Ensembl | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 63
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:76635 Wilanowski T, et al., A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002 Jun;114(1-2):37-50
    • Latest
      J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory