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Polr2h Gene Detail
Summary
  • Symbol
    Polr2h
  • Name
    polymerase (RNA) II (DNA directed) polypeptide H
  • Synonyms
    MGC:8248
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384309
    NCBI Gene: 245841
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20536552-20541015 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384309
 protein coding gene Chr16:20536415-20541017 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022654
 protein coding gene Chr16:18067606-18072106 (+)
A/J MGP_AJ_G0022616
 protein coding gene Chr16:17194670-17199283 (+)
AKR/J MGP_AKRJ_G0022591
 protein coding gene Chr16:17841975-17846577 (+)
BALB/cJ MGP_BALBcJ_G0022620
 protein coding gene Chr16:17350986-17355380 (+)
C3H/HeJ MGP_C3HHeJ_G0022385
 protein coding gene Chr16:18015579-18020192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023071
 protein coding gene Chr16:18423041-18429310 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020589
 protein coding gene Chr16:17878471-17883109 (+)
CAST/EiJ MGP_CASTEiJ_G0021915
 protein coding gene Chr16:17991296-17996105 (+)
CBA/J MGP_CBAJ_G0022357
 protein coding gene Chr16:19174450-19180117 (+)
DBA/2J MGP_DBA2J_G0022489
 protein coding gene Chr16:17122003-17126396 (+)
FVB/NJ MGP_FVBNJ_G0022464
 protein coding gene Chr16:17163329-17168048 (+)
LP/J MGP_LPJ_G0022556
 protein coding gene Chr16:17791524-17795918 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022484
 protein coding gene Chr16:18841200-18846570 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023082
 protein coding gene Chr16:17815136-17820551 (+)
PWK/PhJ MGP_PWKPhJ_G0021656
 protein coding gene Chr16:17391799-17396777 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021486
 protein coding gene Chr16:17615671-17622317 (+)
WSB/EiJ MGP_WSBEiJ_G0021959
 protein coding gene Chr16:17810022-17814378 (+)



Homology
more
  • Human Ortholog
    POLR2H, RNA polymerase II, I and III subunit H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2H, RNA polymerase II, I and III subunit H
  • Synonyms
    RPABC3, RPB17, RPB8
  • Links
    NCBI Gene ID: 5437
    neXtProt AC: NX_P52434
    UniProt: P52434

  • Chr Location
    3q27.1; chr3:184361710-184368596 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    132
  • cDNA Data
    34
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 245841 NCBI Gene Model | MGI Sequence Detail 4464 C57BL/6J ±  kb
    transcript NM_001356423 RefSeq | MGI Sequence Detail 1177 C57BL/6  
    polypeptide Q923G2 UniProt | EBI | MGI Sequence Detail 150 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012994 DNA-directed RNA polymerases I, II, and III subunit RPABC3
      (term hierarchy)
    • InterPro Domains
      IPR005570 DNA-directed RNA polymerases I, II, and III subunit RPABC3
      IPR012340 Nucleic acid-binding, OB-fold
    • GlyGen
      Q923G2 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory