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Nae1 Gene Detail
Summary
  • Symbol
    Nae1
  • Name
    NEDD8 activating enzyme E1 subunit 1
  • Synonyms
    Appbp1, MGC:29435, MGC:36437, MGC:36630
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384561
    NCBI Gene: 234664
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105237660-105261269 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384561
 protein coding gene Chr8:105237660-105261269 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034012
 protein coding gene Chr8:106649731-106676006 (-)
A/J MGP_AJ_G0033993
 protein coding gene Chr8:102417283-102442258 (-)
AKR/J MGP_AKRJ_G0033919
 protein coding gene Chr8:105394348-105419343 (-)
BALB/cJ MGP_BALBcJ_G0033986
 protein coding gene Chr8:102643616-102667395 (-)
C3H/HeJ MGP_C3HHeJ_G0033698
 protein coding gene Chr8:106095515-106122080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034506
 protein coding gene Chr8:110562286-110586115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031449
 protein coding gene Chr8:95693903-95717135 (-)
CAST/EiJ MGP_CASTEiJ_G0033025
 protein coding gene Chr8:105646092-105674277 (-)
CBA/J MGP_CBAJ_G0033672
 protein coding gene Chr8:114220064-114249642 (-)
DBA/2J MGP_DBA2J_G0033826
 protein coding gene Chr8:101784356-101808230 (-)
FVB/NJ MGP_FVBNJ_G0033773
 protein coding gene Chr8:100717976-100741474 (-)
LP/J MGP_LPJ_G0033917
 protein coding gene Chr8:106844453-106869204 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033815
 protein coding gene Chr8:117400245-117427793 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034524
 protein coding gene Chr8:105338390-105362828 (-)
PWK/PhJ MGP_PWKPhJ_G0032727
 protein coding gene Chr8:101191508-101216143 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032566
 protein coding gene Chr8:104159167-104182514 (-)
WSB/EiJ MGP_WSBEiJ_G0033140
 protein coding gene Chr8:106028970-106056259 (-)



Homology
more
  • Human Ortholog
    NAE1, NEDD8 activating enzyme E1 subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAE1, NEDD8 activating enzyme E1 subunit 1
  • Synonyms
    A-116A10.1, APPBP1, HPP1, NEDFIH, ula-1
  • Links
    NCBI Gene ID: 8883
    neXtProt AC: NX_Q13564
    UniProt: Q13564

  • Chr Location
    16q22.1; chr16:66802875-66873256 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homzogyous for a conditional allele activated in adult excitatory forebrain neurons exhibit decreased dendritic spine and size, and impaired CNS synaptic transmission, spatial working memory, and short and long term object recognition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    27
  • cDNA Data
    88
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234664 NCBI Gene Model | MGI Sequence Detail 23610 C57BL/6J ±  kb
    transcript NM_144931 RefSeq | MGI Sequence Detail 1808 C57BL/6  
    polypeptide Q8VBW6 UniProt | EBI | MGI Sequence Detail 534 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010957 NEDD8-activating enzyme E1 regulatory subunit
      (term hierarchy)
    • InterPro Domains
      IPR030667 NEDD8-activating enzyme E1 regulatory subunit APP-BP1
      IPR045886 ThiF/MoeB/HesA family
      IPR000594 THIF-type NAD/FAD binding fold
      IPR035985 Ubiquitin-activating enzyme
    • GlyGen
      Q8VBW6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 88
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:80709 Aubert J, et al., Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol. 2002 Dec;20(12):1240-5
    • Latest
      J:351980 Ayuso-Garcia P, et al., Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination. Sci Adv. 2024 Apr 12;10(15):eadm7600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory