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Ndufs8 Gene Detail
Summary
  • Symbol
    Ndufs8
  • Name
    NADH:ubiquinone oxidoreductase core subunit S8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385079
    NCBI Gene: 225887
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3958863-3962774 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385079
 protein coding gene Chr19:3958863-3962774 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024632
 protein coding gene Chr19:717342-721189 (-)
A/J MGP_AJ_G0024599
 protein coding gene Chr19:684387-688276 (-)
AKR/J MGP_AKRJ_G0024570
 protein coding gene Chr19:693763-697610 (-)
BALB/cJ MGP_BALBcJ_G0024597
 protein coding gene Chr19:694568-698415 (-)
C3H/HeJ MGP_C3HHeJ_G0024366
 protein coding gene Chr19:694944-698836 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025045
 protein coding gene Chr19:719453-723300 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022474
 protein coding gene Chr19:650126-654034 (-)
CAST/EiJ MGP_CASTEiJ_G0023838
 protein coding gene Chr19:708987-712815 (-)
CBA/J MGP_CBAJ_G0024336
 protein coding gene Chr19:785777-789624 (-)
DBA/2J MGP_DBA2J_G0024465
 protein coding gene Chr19:662100-665986 (-)
FVB/NJ MGP_FVBNJ_G0024432
 protein coding gene Chr19:669904-675497 (-)
LP/J MGP_LPJ_G0024551
 protein coding gene Chr19:710169-714016 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024462
 protein coding gene Chr19:752138-756026 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025093
 protein coding gene Chr19:700024-703835 (-)
PWK/PhJ MGP_PWKPhJ_G0023584
 protein coding gene Chr19:686389-690230 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023391
 protein coding gene Chr19:704781-711135 (-)
WSB/EiJ MGP_WSBEiJ_G0023901
 protein coding gene Chr19:690933-694761 (-)



Homology
more
  • Human Ortholog
    NDUFS8, NADH:ubiquinone oxidoreductase core subunit S8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFS8, NADH:ubiquinone oxidoreductase core subunit S8
  • Synonyms
    CI-23k, CI23KD, MC1DN2, TYKY
  • Links
    NCBI Gene ID: 4728
    neXtProt AC: NX_O00217
    UniProt: O00217

  • Chr Location
    11q13.2; chr11:68030617-68036644 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFS8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    11
  • cDNA Data
    85
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225887 NCBI Gene Model | MGI Sequence Detail 3912 C57BL/6J ±  kb
    transcript NM_144870 RefSeq | MGI Sequence Detail 1057 Not Specified  
    polypeptide Q8K3J1 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 85
      Primer pair 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:50639 Schibler L, et al., Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans. Genome Res. 1998 Sep;8(9):901-15
    • Latest
      J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory