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Tesk2 Gene Detail
Summary
  • Symbol
    Tesk2
  • Name
    testis-specific kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385204
    NCBI Gene: 230661
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116578107-116661450 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385204
 protein coding gene Chr4:116578107-116663153 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028634
 protein coding gene Chr4:117638193-117738927 (+)
A/J MGP_AJ_G0028595
 protein coding gene Chr4:113121584-113206451 (+)
AKR/J MGP_AKRJ_G0028545
 protein coding gene Chr4:115557879-115668071 (+)
BALB/cJ MGP_BALBcJ_G0028616
 protein coding gene Chr4:113752444-113840029 (+)
C3H/HeJ MGP_C3HHeJ_G0028330
 protein coding gene Chr4:117127555-117231665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029057
 protein coding gene Chr4:122188661-122278645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026341
 protein coding gene Chr4:107162644-107253571 (+)
CAST/EiJ MGP_CASTEiJ_G0027764
 protein coding gene Chr4:114365945-114462632 (+)
CBA/J MGP_CBAJ_G0028297
 protein coding gene Chr4:125489209-125613210 (+)
DBA/2J MGP_DBA2J_G0028445
 protein coding gene Chr4:113746200-113843273 (+)
FVB/NJ MGP_FVBNJ_G0028413
 protein coding gene Chr4:112256173-112341962 (+)
LP/J MGP_LPJ_G0028547
 protein coding gene Chr4:117839259-117927042 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028440
 protein coding gene Chr4:130495084-130589092 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029094
 protein coding gene Chr4:116723985-116814566 (+)
PWK/PhJ MGP_PWKPhJ_G0027490
 protein coding gene Chr4:110534882-110623986 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027313
 protein coding gene Chr4:112998508-113092258 (+)
WSB/EiJ MGP_WSBEiJ_G0027843
 protein coding gene Chr4:116597726-116689437 (+)



Homology
more
  • Human Ortholog
    TESK2, testis associated actin remodelling kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TESK2, testis associated actin remodelling kinase 2
  • Links
    NCBI Gene ID: 10420
    neXtProt AC: NX_Q96S53
    UniProt: Q96S53

  • Chr Location
    1p34.1; chr1:45343883-45491163 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    77
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    67
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Tesk2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    214 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    99
  • cDNA Data
    24
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 230661 NCBI Gene Model | MGI Sequence Detail 83344 C57BL/6J ±  kb
transcript NM_146151 RefSeq | MGI Sequence Detail 3032 C57BL/6  
polypeptide Q8VCT9 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory