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Eva1a Gene Detail
Summary
  • Symbol
    Eva1a
  • Name
    eva-1 homolog A, regulator of programmed cell death
  • Synonyms
    Fam176a, MGC:25911, MGC:37042, Tmem166
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385247
    NCBI Gene: 232146
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82018058-82070079 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1960 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385247
 protein coding gene Chr6:82018024-82070080 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030903
 protein coding gene Chr6:83000733-83057920 (+)
A/J MGP_AJ_G0030872
 protein coding gene Chr6:79809050-79866817 (+)
AKR/J MGP_AKRJ_G0030800
 protein coding gene Chr6:82083583-82137306 (+)
BALB/cJ MGP_BALBcJ_G0030882
 protein coding gene Chr6:79840300-79904157 (+)
C3H/HeJ MGP_C3HHeJ_G0030828
 protein coding gene Chr6:102200698-102252532 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031342
 protein coding gene Chr6:85256211-85309229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028528
 protein coding gene Chr6:78234508-78287680 (+)
CAST/EiJ MGP_CASTEiJ_G0029991
 protein coding gene Chr6:82101642-82157301 (+)
CBA/J MGP_CBAJ_G0030569
 protein coding gene Chr6:88641464-88699525 (+)
DBA/2J MGP_DBA2J_G0030722
 protein coding gene Chr6:79119688-79188740 (+)
FVB/NJ MGP_FVBNJ_G0030675
 protein coding gene Chr6:78364502-78416482 (+)
LP/J MGP_LPJ_G0030801
 protein coding gene Chr6:82984445-83040071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030711
 protein coding gene Chr6:92961287-93017625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031366
 protein coding gene Chr6:81928585-81983793 (+)
PWK/PhJ MGP_PWKPhJ_G0029706
 protein coding gene Chr6:78023178-78076423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029534
 protein coding gene Chr6:80795897-80854186 (+)
WSB/EiJ MGP_WSBEiJ_G0030072
 protein coding gene Chr6:82369147-82423404 (+)



Homology
more
  • Human Ortholog
    EVA1A, eva-1 homolog A, regulator of programmed cell death
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EVA1A, eva-1 homolog A, regulator of programmed cell death
  • Synonyms
    FAM176A, TMEM166
  • Links
    NCBI Gene ID: 84141
    neXtProt AC: NX_Q9H8M9
    UniProt: Q9H8M9

  • Chr Location
    2p12; chr2:75469302-75569722 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neural cells exhibit impaired neural stem cells exhibit impaired self-renewal and differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    6
  • cDNA Data
    37
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232146 NCBI Gene Model | MGI Sequence Detail 52022 C57BL/6J ±  kb
transcript NM_001411593 RefSeq | MGI Sequence Detail 1911 C57BL/6  
polypeptide Q91WM6 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory