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Kmt5c Gene Detail
Summary
  • Symbol
    Kmt5c
  • Name
    lysine methyltransferase 5C
  • Synonyms
    Suv4-20h2, Suv420h2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385262
    NCBI Gene: 232811
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4743114-4750513 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385262
 protein coding gene Chr7:4743091-4750513 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031557
 protein coding gene Chr7:1667573-1674979 (+)
A/J MGP_AJ_G0031531
 protein coding gene Chr7:1676018-1683970 (+)
AKR/J MGP_AKRJ_G0031460
 protein coding gene Chr7:1743543-1750944 (+)
BALB/cJ MGP_BALBcJ_G0031539
 protein coding gene Chr7:1715670-1723622 (+)
C3H/HeJ MGP_C3HHeJ_G0031260
 protein coding gene Chr7:1716266-1724048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032000
 protein coding gene Chr7:1733283-1740681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029124
 protein coding gene Chr7:1422846-1430086 (+)
CAST/EiJ MGP_CASTEiJ_G0030624
 protein coding gene Chr7:1657629-1666365 (+)
CBA/J MGP_CBAJ_G0031218
 protein coding gene Chr7:1930137-1940056 (+)
DBA/2J MGP_DBA2J_G0031377
 protein coding gene Chr7:1654696-1662320 (+)
FVB/NJ MGP_FVBNJ_G0031329
 protein coding gene Chr7:1620576-1628400 (+)
LP/J MGP_LPJ_G0031462
 protein coding gene Chr7:1776863-1784316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031368
 protein coding gene Chr7:1868175-1875549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032030
 protein coding gene Chr7:1655584-1662969 (+)
PWK/PhJ MGP_PWKPhJ_G0030352
 protein coding gene Chr7:1823512-1830974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030177
 protein coding gene Chr7:1704920-1712612 (+)
WSB/EiJ MGP_WSBEiJ_G0030719
 protein coding gene Chr7:1671608-1679911 (+)



Homology
more
  • Human Ortholog
    KMT5C, lysine methyltransferase 5C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KMT5C, lysine methyltransferase 5C
  • Synonyms
    Suv4-20h2, SUV420H2
  • Links
    NCBI Gene ID: 84787
    neXtProt AC: NX_Q86Y97
    UniProt: Q86Y97

  • Chr Location
    19q13.42; chr19:55339853-55348121 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    1 images
    10 phenotype references
Mice homozygous for a knock-out allele exhibit no apparent defects and develop normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    109
  • cDNA Data
    79
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059851 Ensembl Gene Model | MGI Sequence Detail 7400 C57BL/6J ±  kb
transcript ENSMUST00000098853 Ensembl | MGI Sequence Detail 2189 Not Applicable  
polypeptide ENSMUSP00000096452 Ensembl | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 3
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:313616 Zhang F, et al., Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Front Cell Dev Biol. 2021;9:642931
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory