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Plekhb2 Gene Detail
Summary
  • Symbol
    Plekhb2
  • Name
    pleckstrin homology domain containing, family B (evectins) member 2
  • Synonyms
    2310009M15Rik, evt-2, Phdc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385825
    NCBI Gene: 226971
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:34889057-34918661 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 13.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    983 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385825
 protein coding gene Chr1:34889040-34918666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015916
 protein coding gene Chr1:33284814-33320481 (+)
A/J MGP_AJ_G0015900
 protein coding gene Chr1:32448862-32478927 (+)
AKR/J MGP_AKRJ_G0015855
 protein coding gene Chr1:32859226-32890638 (+)
BALB/cJ MGP_BALBcJ_G0015854
 protein coding gene Chr1:32122022-32151706 (+)
C3H/HeJ MGP_C3HHeJ_G0015687
 protein coding gene Chr1:33069423-33099153 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016307
 protein coding gene Chr1:34789370-34821300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014029
 protein coding gene Chr1:29584484-29618707 (+)
CAST/EiJ MGP_CASTEiJ_G0015268
 protein coding gene Chr1:32954176-32991825 (+)
CBA/J MGP_CBAJ_G0015659
 protein coding gene Chr1:35731811-35761236 (+)
DBA/2J MGP_DBA2J_G0015760
 protein coding gene Chr1:31803405-31833480 (+)
FVB/NJ MGP_FVBNJ_G0015762
 protein coding gene Chr1:31333434-31364028 (+)
LP/J MGP_LPJ_G0015830
 protein coding gene Chr1:33637563-33673565 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015782
 protein coding gene Chr1:37988582-38018095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016354
 protein coding gene Chr1:32870511-32901924 (+)
PWK/PhJ MGP_PWKPhJ_G0015051
 protein coding gene Chr1:31533549-31564727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014833
 protein coding gene Chr1:32848623-32889077 (+)
WSB/EiJ MGP_WSBEiJ_G0015330
 protein coding gene Chr1:32849109-32880085 (+)



Homology
more
  • Human Ortholog
    PLEKHB2, pleckstrin homology domain containing B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHB2, pleckstrin homology domain containing B2
  • Synonyms
    EVT2
  • Links
    NCBI Gene ID: 55041
    neXtProt AC: NX_Q96CS7
    UniProt: Q96CS7

  • Chr Location
    2q21.1; chr2:131104847-131353709 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    185
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026123 Ensembl Gene Model | MGI Sequence Detail 29605 C57BL/6J ±  kb
transcript ENSMUST00000027297 Ensembl | MGI Sequence Detail 3279 Not Applicable  
polypeptide ENSMUSP00000027297 Ensembl | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 186
    cDNA 185
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924835, MGI:2138415
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:78057 Krappa R, et al., Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4633-8
  • Latest
    J:283946 Chatterjee S, et al., Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Proc Natl Acad Sci U S A. 2019 Dec 9;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory