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Mical1 Gene Detail
Summary
  • Symbol
    Mical1
  • Name
    microtubule associated monooxygenase, calponin and LIM domain containing 1
  • Synonyms
    MGC:27831, MGC:38321, Nical
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385847
    NCBI Gene: 171580
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:41352310-41363028 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385847
 protein coding gene Chr10:41351693-41363028 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017173
 protein coding gene Chr10:40118208-40128922 (+)
A/J MGP_AJ_G0017150
 protein coding gene Chr10:39000661-39011379 (+)
AKR/J MGP_AKRJ_G0017110
 protein coding gene Chr10:39586037-39596755 (+)
BALB/cJ MGP_BALBcJ_G0017112
 protein coding gene Chr10:39069621-39080339 (+)
C3H/HeJ MGP_C3HHeJ_G0016933
 protein coding gene Chr10:39901555-39912276 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017571
 protein coding gene Chr10:41341261-41352086 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015267
 protein coding gene Chr10:36938394-36949291 (+)
CAST/EiJ MGP_CASTEiJ_G0016512
 protein coding gene Chr10:40102857-40113722 (+)
CBA/J MGP_CBAJ_G0016907
 protein coding gene Chr10:43226398-43237116 (+)
DBA/2J MGP_DBA2J_G0017012
 protein coding gene Chr10:38504709-38515427 (+)
FVB/NJ MGP_FVBNJ_G0017007
 protein coding gene Chr10:38004268-38014986 (+)
LP/J MGP_LPJ_G0017089
 protein coding gene Chr10:40106241-40116955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017037
 protein coding gene Chr10:44050131-44060849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017608
 protein coding gene Chr10:39567193-39577911 (+)
PWK/PhJ MGP_PWKPhJ_G0016292
 protein coding gene Chr10:38381086-38392058 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016076
 protein coding gene Chr10:39382938-39393701 (+)
WSB/EiJ MGP_WSBEiJ_G0016575
 protein coding gene Chr10:39892724-39903473 (+)



Homology
more
  • Human Ortholog
    MICAL1, microtubule associated monooxygenase, calponin and LIM domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICAL1, microtubule associated monooxygenase, calponin and LIM domain containing 1
  • Synonyms
    MICAL, MICAL-1, NICAL
  • Links
    NCBI Gene ID: 64780
    neXtProt AC: NX_Q8TDZ2
    UniProt: Q8TDZ2

  • Chr Location
    6q21; chr6:109444062-109465968 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO leads to increased mortality after cardiac stress. Mice show impaired lamina-specific targeting of mossy fibre axons onto CA3 pyramidal neurons in the developing hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    60
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019823 Ensembl Gene Model | MGI Sequence Detail 10719 C57BL/6J ±  kb
    transcript ENSMUST00000019967 Ensembl | MGI Sequence Detail 3563 Not Applicable  
    polypeptide ENSMUSP00000019967 Ensembl | MGI Sequence Detail 1048 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:336712 Niu F, et al., F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov;6(45)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory