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Igsf11 Gene Detail
Summary
  • Symbol
    Igsf11
  • Name
    immunoglobulin superfamily, member 11
  • Synonyms
    1700025L02Rik, BT-IgSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388477
    NCBI Gene: 207683
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38713033-38847521 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388477
 protein coding gene Chr16:38712840-38847521 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022824
 protein coding gene Chr16:37448163-37583624 (+)
A/J MGP_AJ_G0022789
 protein coding gene Chr16:35586696-35722158 (+)
AKR/J MGP_AKRJ_G0022761
 protein coding gene Chr16:36935403-37069277 (+)
BALB/cJ MGP_BALBcJ_G0022790
 protein coding gene Chr16:35699994-35834596 (+)
C3H/HeJ MGP_C3HHeJ_G0022554
 protein coding gene Chr16:37029880-37178599 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023237
 protein coding gene Chr16:38309522-38442888 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020752
 protein coding gene Chr16:35954602-36083760 (+)
CAST/EiJ MGP_CASTEiJ_G0022080
 protein coding gene Chr16:37202021-37339305 (+)
CBA/J MGP_CBAJ_G0022525
 protein coding gene Chr16:39979916-40132055 (+)
DBA/2J MGP_DBA2J_G0022657
 protein coding gene Chr16:35461060-35596162 (+)
FVB/NJ MGP_FVBNJ_G0022632
 protein coding gene Chr16:35486495-35617449 (+)
LP/J MGP_LPJ_G0022725
 protein coding gene Chr16:37108412-37243935 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022651
 protein coding gene Chr16:39066443-39216843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023252
 protein coding gene Chr16:36904349-37039667 (+)
PWK/PhJ MGP_PWKPhJ_G0021820
 protein coding gene Chr16:35887576-36014234 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021651
 protein coding gene Chr16:36789147-36915845 (+)
WSB/EiJ MGP_WSBEiJ_G0022124
 protein coding gene Chr16:36964361-37101265 (+)



Homology
more
  • Human Ortholog
    IGSF11, immunoglobulin superfamily member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGSF11, immunoglobulin superfamily member 11
  • Synonyms
    BT-IgSF, BTIGSF, CT119, CXADRL1, Igsf13, VSIG3
  • Links
    NCBI Gene ID: 152404
    neXtProt AC: NX_Q5DX21
    UniProt: Q5DX21

  • Chr Location
    3q13.32; chr3:118900557-119146068 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit disrupted synaptic transmission and plasticity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    27
  • cDNA Data
    18
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022790 Ensembl Gene Model | MGI Sequence Detail 134489 C57BL/6J ±  kb
    transcript ENSMUST00000023478 Ensembl | MGI Sequence Detail 3443 Not Applicable  
    polypeptide ENSMUSP00000023478 Ensembl | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1919108
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346440 Pelz L, et al., The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice. eNeuro. 2024 Feb 22;11(3):ENEURO.0283-23.2024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory