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Unc5d Gene Detail
Summary
  • Symbol
    Unc5d
  • Name
    unc-5 netrin receptor D
  • Synonyms
    D930029E11Rik, Unc5h4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389364
    NCBI Gene: 210801
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:29136745-29709664 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 16.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15780 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389364
 protein coding gene Chr8:29136745-29709698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033511
 protein coding gene Chr8:26928510-27531105 (-)
A/J MGP_AJ_G0033490
 protein coding gene Chr8:25908178-26474252 (-)
AKR/J MGP_AKRJ_G0033415
 protein coding gene Chr8:26729917-27322854 (-)
BALB/cJ MGP_BALBcJ_G0033486
 protein coding gene Chr8:26045951-26614359 (-)
C3H/HeJ MGP_C3HHeJ_G0033200
 protein coding gene Chr8:26991800-27583452 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034003
 protein coding gene Chr8:27984953-28590619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030953
 protein coding gene Chr8:22980044-23520778 (-)
CAST/EiJ MGP_CASTEiJ_G0032526
 protein coding gene Chr8:26438381-27006551 (-)
CBA/J MGP_CBAJ_G0033177
 protein coding gene Chr8:29115181-29729292 (-)
DBA/2J MGP_DBA2J_G0033330
 protein coding gene Chr8:25867495-26431786 (-)
FVB/NJ MGP_FVBNJ_G0033274
 protein coding gene Chr8:25687664-26265000 (-)
LP/J MGP_LPJ_G0033420
 protein coding gene Chr8:26874122-27469614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033317
 protein coding gene Chr8:28564252-29171621 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034022
 protein coding gene Chr8:26709731-27307553 (-)
PWK/PhJ MGP_PWKPhJ_G0032238
 protein coding gene Chr8:25464777-26023891 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032071
 protein coding gene Chr8:26035489-26613935 (-)
WSB/EiJ MGP_WSBEiJ_G0032642
 protein coding gene Chr8:26883367-27467948 (-)



Homology
more
  • Human Ortholog
    UNC5D, unc-5 netrin receptor D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC5D, unc-5 netrin receptor D
  • Synonyms
    PRO34692, Unc5h4
  • Links
    NCBI Gene ID: 137970
    neXtProt AC: NX_Q6UXZ4
    UniProt: Q6UXZ4

  • Chr Location
    8p12; chr8:35235475-35796550 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit impaired induced growth cone collapse response and accelerated radial migration of cortical neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1118
  • Tissues
    175
  • cDNA Data
    13
  • Literature Summary
    43
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063626 Ensembl Gene Model | MGI Sequence Detail 572920 C57BL/6J ±  kb
transcript ENSMUST00000168630 Ensembl | MGI Sequence Detail 9220 Not Applicable  
polypeptide ENSMUSP00000128521 Ensembl | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 14
    Primer pair 4
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444819
References
more
  • Summaries
    All 74
    Developmental Gene Expression 43
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:79319 Engelkamp D, Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech Dev. 2002 Oct;118(1-2):191
  • Latest
    J:339867 Prigge CL, et al., Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling. Dev Cell. 2023 Aug 3;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory