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Maml2 Gene Detail
Summary
  • Symbol
    Maml2
  • Name
    mastermind like transcriptional coactivator 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389460
    NCBI Gene: 270118
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:13298306-13620684 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 3.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8281 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389460
 protein coding gene Chr9:13296547-13620829 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034343
 protein coding gene Chr9:10541910-10631259 (+)
A/J MGP_AJ_G0034320
 protein coding gene Chr9:10269423-10605441 (+)
AKR/J MGP_AKRJ_G0034248
 protein coding gene Chr9:10243192-10574913 (+)
BALB/cJ MGP_BALBcJ_G0034315
 protein coding gene Chr9:10256022-10349763 (+)
C3H/HeJ MGP_C3HHeJ_G0034025
 protein coding gene Chr9:10525311-10862532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034837
 protein coding gene Chr9:10881832-10973863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031775
 protein coding gene Chr9:9852613-9943110 (+)
CAST/EiJ MGP_CASTEiJ_G0033352
 protein coding gene Chr9:10366447-10708674 (+)
CBA/J MGP_CBAJ_G0033999
 protein coding gene Chr9:11369030-11471881 (+)
DBA/2J MGP_DBA2J_G0034156
 protein coding gene Chr9:10375021-10465479 (+)
FVB/NJ MGP_FVBNJ_G0034100
 protein coding gene Chr9:9767949-10092123 (+)
LP/J MGP_LPJ_G0034241
 protein coding gene Chr9:10347227-10680316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034144
 protein coding gene Chr9:12231460-12567439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034855
 protein coding gene Chr9:10273074-10612398 (+)
PWK/PhJ MGP_PWKPhJ_G0033058
 protein coding gene Chr9:10214665-10542370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032895
 protein coding gene Chr9:10593504-10688129 (+)
WSB/EiJ MGP_WSBEiJ_G0033468
 protein coding gene Chr9:10103038-10436416 (+)



Homology
more
  • Human Ortholog
    MAML2, mastermind like transcriptional coactivator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAML2, mastermind like transcriptional coactivator 2
  • Synonyms
    MAM2, MAM-3, MAM3, MLL-MAML2
  • Links
    NCBI Gene ID: 84441
    neXtProt AC: NX_Q8IZL2
    UniProt: Q8IZL2

  • Chr Location
    11q21; chr11:95976598-96343195 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031925 Ensembl Gene Model | MGI Sequence Detail 322379 C57BL/6J ±  kb
transcript ENSMUST00000159294 Ensembl | MGI Sequence Detail 6404 Not Applicable  
polypeptide ENSMUSP00000124083 Ensembl | MGI Sequence Detail 1170 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR046369 Mastermind-like 1-3
    IPR019082 Neurogenic mastermind-like, N-terminal
    IPR046370 Neurogenic mastermind-like, N-terminal domain superfamily
  • GlyGen
    F6U238 4 sites, 4 N-linked glycans (4 sites)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2679714
References
more
  • Summaries
    All 24
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:79612 Wu L, et al., Identification of a family of mastermind-like transcriptional coactivators for Mammalian notch receptors. Mol Cell Biol. 2002 Nov;22(21):7688-700
  • Latest
    J:226670 Moayedi Y, et al., The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. PLoS Genet. 2014 Jan;10(1):e1004055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory