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Nherf4 Gene Detail
Summary
  • Symbol
    Nherf4
  • Name
    NHERF family PDZ scaffold protein 4
  • Synonyms
    NaPi-Cap2, Pdzd3, Pdzk2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429554
    NCBI Gene: 170761
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44158609-44162761 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429554
 protein coding gene Chr9:44158604-44162768 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034696
 protein coding gene Chr9:42719019-42723137 (-)
A/J MGP_AJ_G0034677
 protein coding gene Chr9:41537807-41541959 (-)
AKR/J MGP_AKRJ_G0034603
 protein coding gene Chr9:42398866-42402990 (-)
BALB/cJ MGP_BALBcJ_G0034668
 protein coding gene Chr9:41283636-41287778 (-)
C3H/HeJ MGP_C3HHeJ_G0034379
 protein coding gene Chr9:42847284-42851436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035189
 protein coding gene Chr9:43990130-43994282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032104
 protein coding gene Chr9:41121208-41125164 (-)
CAST/EiJ MGP_CASTEiJ_G0033701
 protein coding gene Chr9:42685706-42689847 (-)
CBA/J MGP_CBAJ_G0034351
 protein coding gene Chr9:45587262-45591414 (-)
DBA/2J MGP_DBA2J_G0034510
 protein coding gene Chr9:41441202-41445356 (-)
FVB/NJ MGP_FVBNJ_G0034451
 protein coding gene Chr9:40689515-40693639 (-)
LP/J MGP_LPJ_G0034591
 protein coding gene Chr9:43016693-43020843 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034495
 protein coding gene Chr9:47443613-47447753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035210
 protein coding gene Chr9:42294236-42298361 (-)
PWK/PhJ MGP_PWKPhJ_G0033407
 protein coding gene Chr9:41312520-41316692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033241
 protein coding gene Chr9:42609396-42613504 (-)
WSB/EiJ MGP_WSBEiJ_G0033814
 protein coding gene Chr9:42328972-42333096 (-)



Homology
more
  • Human Ortholog
    NHERF4, NHERF family PDZ scaffold protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NHERF4, NHERF family PDZ scaffold protein 4
  • Synonyms
    IKEPP, PDZD3, PDZK2
  • Links
    NCBI Gene ID: 79849
    neXtProt AC: NX_Q86UT5
    UniProt: Q86UT5

  • Chr Location
    11q23.3; chr11:119185457-119190223 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    22
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170761 NCBI Gene Model | MGI Sequence Detail 4153 C57BL/6J ±  kb
transcript NM_133226 RefSeq | MGI Sequence Detail 2181 C57BL/6  
polypeptide Q99MJ6 UniProt | EBI | MGI Sequence Detail 498 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 2
Other
Accession IDs
less
MGI:7388571
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:74952 Gisler SM, et al., Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem. 2001 Mar 23;276(12):9206-13
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory