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Rufy1 Gene Detail
Summary
  • Symbol
    Rufy1
  • Name
    RUN and FYVE domain containing 1
  • Synonyms
    3000002E04Rik, Rabip4, ZFYVE12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429762
    NCBI Gene: 216724
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50280113-50321952 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429762
 protein coding gene Chr11:50280113-50322101 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018250
 protein coding gene Chr11:49571389-49615955 (-)
A/J MGP_AJ_G0018218
 protein coding gene Chr11:47671597-47717317 (-)
AKR/J MGP_AKRJ_G0018188
 protein coding gene Chr11:49183821-49226676 (-)
BALB/cJ MGP_BALBcJ_G0018188
 protein coding gene Chr11:47942257-48003104 (-)
C3H/HeJ MGP_C3HHeJ_G0018001
 protein coding gene Chr11:49182710-49225373 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018639
 protein coding gene Chr11:51036492-51079369 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016292
 protein coding gene Chr11:45286119-45328015 (-)
CAST/EiJ MGP_CASTEiJ_G0017563
 protein coding gene Chr11:49164605-49214963 (-)
CBA/J MGP_CBAJ_G0017976
 protein coding gene Chr11:53400750-53454831 (-)
DBA/2J MGP_DBA2J_G0018083
 protein coding gene Chr11:47460367-47500350 (-)
FVB/NJ MGP_FVBNJ_G0018077
 protein coding gene Chr11:47094232-47136302 (-)
LP/J MGP_LPJ_G0018158
 protein coding gene Chr11:49908906-49983201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018102
 protein coding gene Chr11:54918183-54965251 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018683
 protein coding gene Chr11:49286716-49330600 (-)
PWK/PhJ MGP_PWKPhJ_G0017341
 protein coding gene Chr11:47865869-47907880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017136
 protein coding gene Chr11:49000190-49046772 (-)
WSB/EiJ MGP_WSBEiJ_G0017616
 protein coding gene Chr11:48926992-48969435 (-)



Homology
more
  • Human Ortholog
    RUFY1, RUN and FYVE domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RUFY1, RUN and FYVE domain containing 1
  • Synonyms
    RABIP4, ZFYVE12
  • Links
    NCBI Gene ID: 80230
    neXtProt AC: NX_Q96T51
    UniProt: Q96T51

  • Chr Location
    5q35.3; chr5:179550554-179610012 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele show normal methamphetamine-induced locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    20
  • cDNA Data
    37
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020375 Ensembl Gene Model | MGI Sequence Detail 41840 C57BL/6J ±  kb
transcript ENSMUST00000020643 Ensembl | MGI Sequence Detail 2688 Not Applicable  
polypeptide ENSMUSP00000020643 Ensembl | MGI Sequence Detail 712 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 38
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917456
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory