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Washc4 Gene Detail
Summary
  • Symbol
    Washc4
  • Name
    WASH complex subunit 4
  • Synonyms
    A230046K03Rik, mKIAA1033
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441787
    NCBI Gene: 319277
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:83379616-83432337 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441787
 protein coding gene Chr10:83379073-83432350 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017587
 protein coding gene Chr10:84354809-84407119 (+)
A/J MGP_AJ_G0017567
 protein coding gene Chr10:81504445-81557519 (+)
AKR/J MGP_AKRJ_G0017526
 protein coding gene Chr10:83757765-83809958 (+)
BALB/cJ MGP_BALBcJ_G0017530
 protein coding gene Chr10:81755529-81811220 (+)
C3H/HeJ MGP_C3HHeJ_G0017352
 protein coding gene Chr10:83852200-83906238 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017987
 protein coding gene Chr10:87258385-87314572 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015671
 protein coding gene Chr10:77203046-77255040 (+)
CAST/EiJ MGP_CASTEiJ_G0016919
 protein coding gene Chr10:83726672-83782174 (+)
CBA/J MGP_CBAJ_G0017322
 protein coding gene Chr10:90878111-90936226 (+)
DBA/2J MGP_DBA2J_G0017428
 protein coding gene Chr10:80656401-80708936 (+)
FVB/NJ MGP_FVBNJ_G0017422
 protein coding gene Chr10:79894741-79947688 (+)
LP/J MGP_LPJ_G0017500
 protein coding gene Chr10:84997068-85052284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017450
 protein coding gene Chr10:92537623-92595031 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018024
 protein coding gene Chr10:83694143-83746882 (+)
PWK/PhJ MGP_PWKPhJ_G0016700
 protein coding gene Chr10:80524404-80577422 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016490
 protein coding gene Chr10:82299490-82353054 (+)
WSB/EiJ MGP_WSBEiJ_G0016978
 protein coding gene Chr10:83708877-83763378 (+)



Homology
more
  • Human Ortholog
    WASHC4, WASH complex subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASHC4, WASH complex subunit 4
  • Synonyms
    KIAA1033, MRT43, SWIP
  • Links
    NCBI Gene ID: 23325
    neXtProt AC: NX_Q2M389
    UniProt: Q2M389

  • Chr Location
    12q23.3; chr12:105107324-105169130 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Washc4 mouse models; 1 with human WASHC4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. Homozygous p.P1019R mutation causes endo-lysosomal disruption, leading to accumulation of neurodegenerative markers and progressive cognitive deficits and motor impairments.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034560 Ensembl Gene Model | MGI Sequence Detail 52722 C57BL/6J ±  kb
    transcript ENSMUST00000038388 Ensembl | MGI Sequence Detail 5858 Not Applicable  
    polypeptide ENSMUSP00000039322 Ensembl | MGI Sequence Detail 1173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143496
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory