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Gak Gene Detail
Summary
  • Symbol
    Gak
  • Name
    cyclin G associated kinase
  • Synonyms
    D130045N16Rik, MGC:31204
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442153
    NCBI Gene: 231580
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108717277-108777621 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1478 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442153
 protein coding gene Chr5:108716973-108777643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029859
 protein coding gene Chr5:110691826-110758992 (-)
A/J MGP_AJ_G0029823
 protein coding gene Chr5:106435546-106496197 (-)
AKR/J MGP_AKRJ_G0029768
 protein coding gene Chr5:109861678-109925884 (-)
BALB/cJ MGP_BALBcJ_G0029835
 protein coding gene Chr5:107574953-107635884 (-)
C3H/HeJ MGP_C3HHeJ_G0029557
 protein coding gene Chr5:110360116-110428230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030289
 protein coding gene Chr5:115210837-115277714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027523
 protein coding gene Chr5:101449355-101512817 (-)
CAST/EiJ MGP_CASTEiJ_G0028971
 protein coding gene Chr5:109249175-109311756 (-)
CBA/J MGP_CBAJ_G0029525
 protein coding gene Chr5:119099833-119168862 (-)
DBA/2J MGP_DBA2J_G0029671
 protein coding gene Chr5:106563007-106623908 (-)
FVB/NJ MGP_FVBNJ_G0029628
 protein coding gene Chr5:105290000-105354023 (-)
LP/J MGP_LPJ_G0029759
 protein coding gene Chr5:111274785-111337582 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029660
 protein coding gene Chr5:123990063-124054076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030323
 protein coding gene Chr5:109419203-109479231 (-)
PWK/PhJ MGP_PWKPhJ_G0028684
 protein coding gene Chr5:105383770-105445986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028522
 protein coding gene Chr5:106946841-107010847 (-)
WSB/EiJ MGP_WSBEiJ_G0029044
 protein coding gene Chr5:109739440-109802967 (-)



Homology
more
  • Human Ortholog
    GAK, cyclin G associated kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAK, cyclin G associated kinase
  • Synonyms
    DNAJ26, DNAJC26
  • Links
    NCBI Gene ID: 2580
    neXtProt AC: NX_O14976
    UniProt: O14976

  • Chr Location
    4p16.3; chr4:849276-932373 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 6 genetic backgrounds
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of the kinase domain display neonatal lethality with abnormal lung alveolar morphology and development. Mice homozygous for a knock-out allele exhibit lethality during early development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    37
  • cDNA Data
    148
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062234 Ensembl Gene Model | MGI Sequence Detail 60345 C57BL/6J ±  kb
    transcript ENSMUST00000046603 Ensembl | MGI Sequence Detail 4453 Not Applicable  
    polypeptide ENSMUSP00000036705 Ensembl | MGI Sequence Detail 1305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 149

      Microarray probesets 5
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:301922 Tian X, et al., Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. JCI Insight. 2020 Nov 19;5(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory