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Syne3 Gene Detail
Summary
  • Symbol
    Syne3
  • Name
    spectrin repeat containing, nuclear envelope family member 3
  • Synonyms
    4831426I19Rik, nesprin-3, nesprin-3alpha, nesprin-3beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442408
    NCBI Gene: 212073
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104896192-104976068 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 54.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2899 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442408
 protein coding gene Chr12:104896192-104976357 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020082
 protein coding gene Chr12:106756449-106809520 (-)
A/J MGP_AJ_G0020036
 protein coding gene Chr12:102702761-102746230 (-)
AKR/J MGP_AKRJ_G0020013
 protein coding gene Chr12:105659644-105713740 (-)
BALB/cJ MGP_BALBcJ_G0020022
 protein coding gene Chr12:103110514-103160370 (-)
C3H/HeJ MGP_C3HHeJ_G0019825
 protein coding gene Chr12:106136970-106185411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020468
 protein coding gene Chr12:110053502-110101682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018081
 protein coding gene Chr12:99416717-99494832 (-)
CAST/EiJ MGP_CASTEiJ_G0019366
 protein coding gene Chr12:100972609-101065297 (-)
CBA/J MGP_CBAJ_G0019792
 protein coding gene Chr12:114309157-114354857 (-)
DBA/2J MGP_DBA2J_G0019909
 protein coding gene Chr12:102250854-102298392 (-)
FVB/NJ MGP_FVBNJ_G0019894
 protein coding gene Chr12:101040656-101086216 (-)
LP/J MGP_LPJ_G0019984
 protein coding gene Chr12:106622848-106689472 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019932
 protein coding gene Chr12:117755317-117807022 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020497
 protein coding gene Chr12:105088411-105165245 (-)
PWK/PhJ MGP_PWKPhJ_G0019129
 protein coding gene Chr12:96770984-96831218 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018931
 protein coding gene Chr12:99359947-99406780 (-)
WSB/EiJ MGP_WSBEiJ_G0019425
 protein coding gene Chr12:106069598-106120063 (-)



Homology
more
  • Human Ortholog
    SYNE3, spectrin repeat containing nuclear envelope family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYNE3, spectrin repeat containing nuclear envelope family member 3
  • Synonyms
    C14orf139, C14orf49, KASH3, LINC00341, NCRNA00341, Nesp3, NET53
  • Links
    NCBI Gene ID: 161176
    neXtProt AC: NX_Q6ZMZ3
    UniProt: Q6ZMZ3

  • Chr Location
    14q32.13; chr14:95407266-95516650 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    40
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054150 Ensembl Gene Model | MGI Sequence Detail 79877 C57BL/6J ±  kb
    transcript ENSMUST00000095439 Ensembl | MGI Sequence Detail 3357 Not Applicable  
    polypeptide ENSMUSP00000093090 Ensembl | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory