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Thoc2 Gene Detail
Summary
  • Symbol
    Thoc2
  • Name
    THO complex 2
  • Synonyms
    6330441O12Rik, D130005M13Rik, LOC382210, LOC386493
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442413
    NCBI Gene: 331401
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:40883869-41000878 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 23.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442413
 protein coding gene ChrX:40883868-41009551 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035673
 protein coding gene ChrX:36838677-36965028 (-)
A/J MGP_AJ_G0035656
 protein coding gene ChrX:36817759-36947266 (-)
AKR/J MGP_AKRJ_G0035576
 protein coding gene ChrX:37682862-37823258 (-)
BALB/cJ MGP_BALBcJ_G0035642
 protein coding gene ChrX:36496493-36634955 (-)
C3H/HeJ MGP_C3HHeJ_G0035346
 protein coding gene ChrX:37171893-37295042 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036171
 protein coding gene ChrX:37656781-37789749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033023
 protein coding gene ChrX:34936314-35053261 (-)
CAST/EiJ MGP_CASTEiJ_G0034637
 protein coding gene ChrX:25004159-25130920 (-)
CBA/J MGP_CBAJ_G0035320
 protein coding gene ChrX:38632593-38770114 (-)
DBA/2J MGP_DBA2J_G0035474
 protein coding gene ChrX:36629642-36753600 (-)
FVB/NJ MGP_FVBNJ_G0035423
 protein coding gene ChrX:36354667-36486625 (-)
LP/J MGP_LPJ_G0035562
 protein coding gene ChrX:37166982-37292845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035461
 protein coding gene ChrX:39357057-39523347 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036189
 protein coding gene ChrX:36796284-36927235 (-)
PWK/PhJ MGP_PWKPhJ_G0034336
 protein coding gene ChrX:24563226-24684480 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034181
 protein coding gene ChrX:25561844-25689105 (-)
WSB/EiJ MGP_WSBEiJ_G0034781
 protein coding gene ChrX:36442881-36575401 (-)



Homology
more
  • Human Ortholog
    THOC2, THO complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THOC2, THO complex subunit 2
  • Synonyms
    CXorf3, dJ506G2.1, hTREX120, MRX12, MRX35, THO2, XLID12
  • Links
    NCBI Gene ID: 57187
    neXtProt AC: NX_Q8NI27
    UniProt: Q8NI27

  • Chr Location
    Xq25; chrX:123600561-123733056 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thoc2 mouse models; 1 with human THOC2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a hypomorphic allele display partial lethality before implantation, decreased body and organ size and weight, learning and fine motor coordination deficits, and neurological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    96
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 331401 NCBI Gene Model | MGI Sequence Detail 117010 C57BL/6J ±  kb
    transcript NM_001033422 RefSeq | MGI Sequence Detail 7631 C57BL/6  
    polypeptide B1AZI6 UniProt | EBI | MGI Sequence Detail 1594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000016311 THO complex subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR040007 THO complex subunit 2
      IPR032302 THO complex subunit 2, N-terminal domain
      IPR021418 THO complex, subunitTHOC2, C-terminal
      IPR021726 THO complex, subunitTHOC2, N-terminal
    • GlyGen
      B1AZI6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 96
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2685985, MGI:2686639, MGI:3036266
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345229 Bhattacharjee R, et al., Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Nat Commun. 2024 Feb 8;15(1):1210
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory