Frmd3 MGI Mouse Gene Detail - MGI:2442466

Symbol

Frmd3
Name

FERM domain containing 3
Synonyms

4.1O, 9430066I12Rik, EPB41L4O, P410

Feature Type

protein coding gene
IDs

MGI:2442466
NCBI Gene: 242506
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:73931679-74120451 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 36.06 cM
Mapping Data

1 experiment

SNPs within 2kb

5929 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442466	protein coding gene	Chr4:73931454-74120451 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028389	protein coding gene	Chr4:73249795-73457300 (+)
A/J	MGP_AJ_G0028349	protein coding gene	Chr4:70798197-70985469 (+)
AKR/J	MGP_AKRJ_G0028298	protein coding gene	Chr4:72520550-72715542 (+)
BALB/cJ	MGP_BALBcJ_G0028369	protein coding gene	Chr4:70933383-71122045 (+)
C3H/HeJ	MGP_C3HHeJ_G0028084	protein coding gene	Chr4:73129648-73318088 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028809	protein coding gene	Chr4:76039927-76247270 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026111	protein coding gene	Chr4:67253525-67435117 (+)
CAST/EiJ	MGP_CASTEiJ_G0027525	protein coding gene	Chr4:71113131-71326170 (+)
CBA/J	MGP_CBAJ_G0028053	protein coding gene	Chr4:78436319-78645304 (+)
DBA/2J	MGP_DBA2J_G0028202	protein coding gene	Chr4:70566818-70751074 (+)
FVB/NJ	MGP_FVBNJ_G0028168	protein coding gene	Chr4:69648182-69836738 (+)
LP/J	MGP_LPJ_G0028302	protein coding gene	Chr4:73643659-73826405 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028197	protein coding gene	Chr4:82390010-82643017 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028845	protein coding gene	Chr4:72688716-72872499 (+)
PWK/PhJ	MGP_PWKPhJ_G0027251	protein coding gene	Chr4:69021552-69199743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027076	protein coding gene	Chr4:70099296-70299779 (+)
WSB/EiJ	MGP_WSBEiJ_G0027601	protein coding gene	Chr4:72740085-72935811 (+)

Human Ortholog

FRMD3, FERM domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FRMD3, FERM domain containing 3
Synonyms

4.1O, EPB41L4O, EPB41LO, P410
Links

HGNC:24125

NCBI Gene ID: 257019

neXtProt AC: NX_A2A2Y4

UniProt: A2A2Y4
Chr Location

9q21.32; chr9:83242990-83585794 (-) GRCh38

MGI Vertebrate Homology

Frmd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FRMD3
Gene Tree

Frmd3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

4
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving Frmd3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase frmd3

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All Sequences

43
RefSeq

6
UniProt

2
CCDS

CCDS38789.1, CCDS51212.1

Ensembl

ENSMUSG00000049122 (Evidence)
NCBI Gene

242506

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049122	Ensembl Gene Model \| MGI Sequence Detail	188773	C57BL/6J	± kb
transcript	ENSMUST00000084474	Ensembl \| MGI Sequence Detail	4136	Not Applicable
polypeptide	ENSMUSP00000081514	Ensembl \| MGI Sequence Detail	595	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007665 FERM domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR019749 Band 4.1 domain

IPR000798 Ezrin/radixin/moesin-like

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR014847 FERM adjacent

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR011993 PH-like domain superfamily

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q8BHD4 1 site, 1 N-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 28

Gene Ontology 3

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:350496 Ma J, et al., Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway. Sci Adv. 2024 Jul 5;10(27):eadk8958

TSS for Frmd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37633	Chr4:73931831-73931911 (+)	192 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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