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Cpeb2 Gene Detail
Summary
  • Symbol
    Cpeb2
  • Name
    cytoplasmic polyadenylation element binding protein 2
  • Synonyms
    A630055H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442640
    NCBI Gene: 231207
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:43390513-43447067 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 23.65 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442640
 protein coding gene Chr5:43382692-43447067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029521
 protein coding gene Chr5:41841758-41902990 (+)
A/J MGP_AJ_G0029487
 protein coding gene Chr5:40411025-40466018 (+)
AKR/J MGP_AKRJ_G0029437
 protein coding gene Chr5:41851209-41907475 (+)
BALB/cJ MGP_BALBcJ_G0029498
 protein coding gene Chr5:40881162-40937817 (+)
C3H/HeJ MGP_C3HHeJ_G0029221
 protein coding gene Chr5:41825795-41885193 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029952
 protein coding gene Chr5:43888223-43948218 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027191
 protein coding gene Chr5:37674896-37731536 (+)
CAST/EiJ MGP_CASTEiJ_G0028629
 protein coding gene Chr5:40930439-40987566 (+)
CBA/J MGP_CBAJ_G0029190
 protein coding gene Chr5:45024183-45090597 (+)
DBA/2J MGP_DBA2J_G0029335
 protein coding gene Chr5:40510104-40567068 (+)
FVB/NJ MGP_FVBNJ_G0029296
 protein coding gene Chr5:39922930-39978805 (+)
LP/J MGP_LPJ_G0029421
 protein coding gene Chr5:42291025-42358085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029324
 protein coding gene Chr5:45844953-45913183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029985
 protein coding gene Chr5:41345952-41402798 (+)
PWK/PhJ MGP_PWKPhJ_G0028353
 protein coding gene Chr5:39637134-39692546 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028187
 protein coding gene Chr5:40787703-40854673 (+)
WSB/EiJ MGP_WSBEiJ_G0028710
 protein coding gene Chr5:41418668-41475968 (+)



Homology
more
  • Human Ortholog
    CPEB2, cytoplasmic polyadenylation element binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPEB2, cytoplasmic polyadenylation element binding protein 2
  • Synonyms
    CPEB-2, CPE-BP2, hCPEB-2
  • Links
    NCBI Gene ID: 132864
    neXtProt AC: NX_Q7Z5Q1
    UniProt: Q7Z5Q1

  • Chr Location
    4p15.32; chr4:15002481-15070153 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early postnatal lethality, decreased heart rate, and increased parasympathetic signaling leading to increased pulmonary acetylcholine level, bronchoconstriction, severe apnea, and abnormal breathing patterns.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    22
  • cDNA Data
    34
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039782 Ensembl Gene Model | MGI Sequence Detail 56555 C57BL/6J ±  kb
    transcript ENSMUST00000166713 Ensembl | MGI Sequence Detail 7139 Not Applicable  
    polypeptide ENSMUSP00000130921 Ensembl | MGI Sequence Detail 1022 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005806 cytoplasmic polyadenylation element-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q812E0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 34
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:325988 Jeong Y, et al., Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst. Reproduction. 2022 Feb 24;163(4):233-240
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory