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Dsel Gene Detail
Summary
  • Symbol
    Dsel
  • Name
    dermatan sulfate epimerase-like
  • Synonyms
    9330132E09Rik, DS-epi2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442948
    NCBI Gene: 319901
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:111786432-111792648 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442948
 protein coding gene Chr1:111786431-111792782 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016387
 protein coding gene Chr1:114262674-114268889 (-)
A/J MGP_AJ_G0016367
 protein coding gene Chr1:110168739-110174954 (-)
AKR/J MGP_AKRJ_G0016331
 protein coding gene Chr1:113261397-113267613 (-)
BALB/cJ MGP_BALBcJ_G0016327
 protein coding gene Chr1:110350010-110356225 (-)
C3H/HeJ MGP_C3HHeJ_G0016154
 protein coding gene Chr1:113737051-113743266 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016786
 protein coding gene Chr1:118610501-118616717 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014504
 protein coding gene Chr1:104039337-104045550 (-)
CAST/EiJ MGP_CASTEiJ_G0015737
 protein coding gene Chr1:112642172-112648392 (-)
CBA/J MGP_CBAJ_G0016126
 protein coding gene Chr1:122678569-122684784 (-)
DBA/2J MGP_DBA2J_G0016233
 protein coding gene Chr1:109253522-109259738 (-)
FVB/NJ MGP_FVBNJ_G0016232
 protein coding gene Chr1:108099658-108105874 (-)
LP/J MGP_LPJ_G0016306
 protein coding gene Chr1:115598688-115604903 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016259
 protein coding gene Chr1:128173896-128180111 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016824
 protein coding gene Chr1:113270059-113276275 (-)
PWK/PhJ MGP_PWKPhJ_G0015522
 protein coding gene Chr1:108280163-108286382 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015310
 protein coding gene Chr1:111849926-111856154 (-)
WSB/EiJ MGP_WSBEiJ_G0015799
 protein coding gene Chr1:113175173-113181389 (-)



Homology
more
  • Human Ortholog
    DSEL, dermatan sulfate epimerase like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSEL, dermatan sulfate epimerase like
  • Synonyms
    C18orf4, DE-epi2
  • Links
    NCBI Gene ID: 92126
    neXtProt AC: NX_Q8IZU8
    UniProt: Q8IZU8

  • Chr Location
    18q22.1; chr18:67506587-67516720 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced epimerase activity in the skin, lung, liver, spleen, kidney and brain and reduced iduronic acid content in the brain and kidney chondroitin sulfate/dermatan sulfate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    36
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038702 Ensembl Gene Model | MGI Sequence Detail 6217 C57BL/6J ±  kb
transcript ENSMUST00000035462 Ensembl | MGI Sequence Detail 5759 Not Applicable  
polypeptide ENSMUSP00000043570 Ensembl | MGI Sequence Detail 1207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 36
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:244896 Stachtea XN, et al., Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. PLoS One. 2015;10(10):e0140279
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory