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Plch2 Gene Detail
Summary
  • Symbol
    Plch2
  • Name
    phospholipase C, eta 2
  • Synonyms
    A930027K05Rik, PLCeta2, Plcl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443078
    NCBI Gene: 269615
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155067572-155141241 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1899 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443078
 protein coding gene Chr4:155067572-155148548 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029205
 protein coding gene Chr4:159270037-159343878 (-)
A/J MGP_AJ_G0029170
 protein coding gene Chr4:152586774-152663771 (-)
AKR/J MGP_AKRJ_G0029118
 protein coding gene Chr4:156746594-156820153 (-)
BALB/cJ MGP_BALBcJ_G0029186
 protein coding gene Chr4:153060652-153134378 (-)
C3H/HeJ MGP_C3HHeJ_G0028907
 protein coding gene Chr4:157280907-157354126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029635
 protein coding gene Chr4:164964368-165042862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026881
 protein coding gene Chr4:144887409-144962184 (-)
CAST/EiJ MGP_CASTEiJ_G0028320
 protein coding gene Chr4:154712424-154786001 (-)
CBA/J MGP_CBAJ_G0028869
 protein coding gene Chr4:169904083-169981111 (-)
DBA/2J MGP_DBA2J_G0029018
 protein coding gene Chr4:152611042-152684433 (-)
FVB/NJ MGP_FVBNJ_G0028982
 protein coding gene Chr4:151838609-151914889 (-)
LP/J MGP_LPJ_G0029108
 protein coding gene Chr4:159192032-159271599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029009
 protein coding gene Chr4:172779523-172854964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029667
 protein coding gene Chr4:157343142-157419551 (-)
PWK/PhJ MGP_PWKPhJ_G0028040
 protein coding gene Chr4:148733077-148809058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027874
 protein coding gene Chr4:151618840-151696872 (-)
WSB/EiJ MGP_WSBEiJ_G0028400
 protein coding gene Chr4:157504840-157581067 (-)



Homology
more
  • Human Ortholog
    PLCH2, phospholipase C eta 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCH2, phospholipase C eta 2
  • Synonyms
    PLC-eta2, PLCeta2, PLC-L4, PLCL4
  • Links
    NCBI Gene ID: 9651
    neXtProt AC: NX_O75038
    UniProt: O75038

  • Chr Location
    1p36.32; chr1:2415943-2505532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a reporter allele exhibit no apparent abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    109
  • cDNA Data
    40
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029055 Ensembl Gene Model | MGI Sequence Detail 73670 C57BL/6J ±  kb
transcript ENSMUST00000105631 Ensembl | MGI Sequence Detail 5053 Not Applicable  
polypeptide ENSMUSP00000101256 Ensembl | MGI Sequence Detail 1501 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000012839 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
    (term hierarchy)
  • EC
    3.1.4.11
  • InterPro Domains
    IPR028393 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, catalytic domain
    IPR046971 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, EF-hand motif
    IPR000008 C2 domain
    IPR035892 C2 domain superfamily
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR011993 PH-like domain superfamily
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    IPR001849 Pleckstrin homology domain
  • GlyGen
    A2AP18 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 40
    cDNA 40

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:196071 van der Weyden L, et al., Cancer of mice and men: old twists and new tails. J Pathol. 2013 May;230(1):4-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory