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Nceh1 Gene Detail
Summary
  • Symbol
    Nceh1
  • Name
    neutral cholesterol ester hydrolase 1
  • Synonyms
    Aadacl1, B230106I24Rik, CPO-BP, mKIAA1363
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443191
    NCBI Gene: 320024
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27237153-27299112 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1768 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443191
 protein coding gene Chr3:27237114-27338757 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027109
 protein coding gene Chr3:24492242-24598950 (+)
A/J MGP_AJ_G0027069
 protein coding gene Chr3:24311171-24411502 (+)
AKR/J MGP_AKRJ_G0027038
 protein coding gene Chr3:24609810-24711022 (+)
BALB/cJ MGP_BALBcJ_G0027081
 protein coding gene Chr3:23994862-24094709 (+)
C3H/HeJ MGP_C3HHeJ_G0026822
 protein coding gene Chr3:24656746-24770089 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027526
 protein coding gene Chr3:25852254-25978738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024888
 protein coding gene Chr3:22332295-22394801 (+)
CAST/EiJ MGP_CASTEiJ_G0026277
 protein coding gene Chr3:24489773-24593336 (+)
CBA/J MGP_CBAJ_G0026800
 protein coding gene Chr3:26527254-26636028 (+)
DBA/2J MGP_DBA2J_G0026934
 protein coding gene Chr3:23867884-23968036 (+)
FVB/NJ MGP_FVBNJ_G0026902
 protein coding gene Chr3:23343932-23443098 (+)
LP/J MGP_LPJ_G0027046
 protein coding gene Chr3:25169960-25275329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026923
 protein coding gene Chr3:29120978-29224073 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027586
 protein coding gene Chr3:24336119-24437624 (+)
PWK/PhJ MGP_PWKPhJ_G0026010
 protein coding gene Chr3:23323108-23426224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025820
 protein coding gene Chr3:23894007-23951638 (+)
WSB/EiJ MGP_WSBEiJ_G0026350
 protein coding gene Chr3:24381001-24487867 (+)



Homology
more
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
  • Synonyms
    AADACL1, NCEH
  • Links
    NCBI Gene ID: 57552
    neXtProt AC: NX_Q6PIU2
    UniProt: Q6PIU2

  • Chr Location
    3q26.31; chr3:172630249-172711218 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal organophosphorus metabolism and cholesterol homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    20
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320024 NCBI Gene Model | MGI Sequence Detail 61960 C57BL/6J ±  kb
transcript NM_178772 RefSeq | MGI Sequence Detail 4441 C57BL/6  
polypeptide Q8BLF1 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 7
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory