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Fstl4 Gene Detail
Summary
  • Symbol
    Fstl4
  • Name
    follistatin-like 4
  • Synonyms
    B230374F23Rik, SPIG1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443199
    NCBI Gene: 320027
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:52655461-53079365 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12072 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443199
 protein coding gene Chr11:52655320-53083277 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018286
 protein coding gene Chr11:52114296-52549601 (+)
A/J MGP_AJ_G0018255
 protein coding gene Chr11:50165410-50586783 (+)
AKR/J MGP_AKRJ_G0018225
 protein coding gene Chr11:51792378-52229023 (+)
BALB/cJ MGP_BALBcJ_G0018226
 protein coding gene Chr11:50506016-50937975 (+)
C3H/HeJ MGP_C3HHeJ_G0018037
 protein coding gene Chr11:51757015-52194049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018678
 protein coding gene Chr11:53689711-54130062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016328
 protein coding gene Chr11:47646193-48112926 (+)
CAST/EiJ MGP_CASTEiJ_G0017602
 protein coding gene Chr11:51796765-52236328 (+)
CBA/J MGP_CBAJ_G0018012
 protein coding gene Chr11:56220242-56675249 (+)
DBA/2J MGP_DBA2J_G0018122
 protein coding gene Chr11:49906623-50332020 (+)
FVB/NJ MGP_FVBNJ_G0018114
 protein coding gene Chr11:49548022-49970523 (+)
LP/J MGP_LPJ_G0018196
 protein coding gene Chr11:52550359-52992818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018138
 protein coding gene Chr11:57554428-58008942 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018720
 protein coding gene Chr11:51832184-52261982 (+)
PWK/PhJ MGP_PWKPhJ_G0017377
 protein coding gene Chr11:50402514-50838928 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017172
 protein coding gene Chr11:51632854-52075782 (+)
WSB/EiJ MGP_WSBEiJ_G0017649
 protein coding gene Chr11:51448143-51889414 (+)



Homology
more
  • Human Ortholog
    FSTL4, follistatin like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSTL4, follistatin like 4
  • Links
    NCBI Gene ID: 23105
    neXtProt AC: NX_Q6MZW2
    UniProt: Q6MZW2

  • Chr Location
    5q31.1; chr5:133196455-133842067 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Homozygous null mice were born at expected Mendelian ratio and healthy, fertile, apparently normal with normal retinal laminar structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    6
  • cDNA Data
    5
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036264 Ensembl Gene Model | MGI Sequence Detail 423905 C57BL/6J ±  kb
transcript ENSMUST00000036796 Ensembl | MGI Sequence Detail 4380 Not Applicable  
polypeptide ENSMUSP00000042007 Ensembl | MGI Sequence Detail 841 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:338268 Dos Santos M, et al., Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution. Nat Commun. 2023 Jul 19;14(1):4333
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory