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Dlx6os1 Gene Detail
Summary
  • Symbol
    Dlx6os1
  • Name
    distal-less homeobox 6, opposite strand 1
  • Synonyms
    A230055N17Rik, Dlx6as1, Dlx6os1, Evf-1, Evf1, Evf1/2, Evf-2, Evf2, mEvf-1, Shhrs
Location &
Maps
more
  • Sequence Map
    Chr6:6820543-6871627 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443217
 antisense lncRNA gene Chr6:6749740-6871632 (-)
129S1/SvImJ MGP_129S1SvImJ_G0004230
 antisense lncRNA gene Chr6:3735930-3791804 (-)
A/J MGP_AJ_G0004208
 antisense lncRNA gene Chr6:3591318-3642891 (-)
AKR/J MGP_AKRJ_G0004189
 antisense lncRNA gene Chr6:3694125-3748897 (-)
BALB/cJ MGP_BALBcJ_G0004195
 antisense lncRNA gene Chr6:3542852-3596044 (-)
C3H/HeJ MGP_C3HHeJ_G0004143
 antisense lncRNA gene Chr6:3630522-3686399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0004344
 antisense lncRNA gene Chr6:3821772-3879441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0003817
 antisense lncRNA gene Chr6:3213335-3253235 (-)
CAST/EiJ MGP_CASTEiJ_G0004105
 antisense lncRNA gene Chr6:3649742-3705840 (-)
CBA/J MGP_CBAJ_G0004137
 antisense lncRNA gene Chr6:3968613-4020941 (-)
DBA/2J MGP_DBA2J_G0004153
 antisense lncRNA gene Chr6:3531115-3583052 (-)
FVB/NJ MGP_FVBNJ_G0004169
 antisense lncRNA gene Chr6:3515735-3568762 (-)
LP/J MGP_LPJ_G0004231
 antisense lncRNA gene Chr6:3683056-3736029 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0004159
 antisense lncRNA gene Chr6:3997044-4054371 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0004341
 antisense lncRNA gene Chr6:3630448-3687555 (-)
PWK/PhJ MGP_PWKPhJ_G0004058
 antisense lncRNA gene Chr6:3469705-3522431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0004002
 antisense lncRNA gene Chr6:3689264-3740256 (-)
WSB/EiJ MGP_WSBEiJ_G0004141
 antisense lncRNA gene Chr6:3629000-3683793 (-)



Homology
more
  • Human Ortholog
    DLX6-AS1, DLX6 antisense RNA 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX6-AS1, DLX6 antisense RNA 1
  • Synonyms
    DLX6-AS, DLX6AS, Evf-2, NCRNA00212
  • Links
    NCBI Gene ID: 285987

  • Chr Location
    7q21.3; chr7:96955141-97014088 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit temporary loss of GABAergic interneurons and decreased inhibitory postsynaptic currents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    925
  • Tissues
    95
  • cDNA Data
    22
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      45
    • RefSeq
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320038 NCBI Gene Model | MGI Sequence Detail 51085 C57BL/6J ±  kb
    transcript NR_015388 RefSeq | MGI Sequence Detail 4266 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 22
      Primer pair 6
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 1
      Phenotypes 15
    • Earliest
      J:76480 Robledo RF, et al., The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1;16(9):1089-101
    • Latest
      J:345332 Guo J, et al., Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3beta signaling pathway. Cell Death Dis. 2023 Feb 28;14(2):172
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory