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Tom1l2 Gene Detail
Summary
  • Symbol
    Tom1l2
  • Name
    target of myb1-like 2 (chicken)
  • Synonyms
    2900016I08Rik, A730055F12Rik, myb1-like protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443306
    NCBI Gene: 216810
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60117540-60243731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3086 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443306
 protein coding gene Chr11:60114622-60243766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018414
 protein coding gene Chr11:60095491-60227389 (-)
A/J MGP_AJ_G0018383
 protein coding gene Chr11:57815583-57943190 (-)
AKR/J MGP_AKRJ_G0018353
 protein coding gene Chr11:59747424-59878236 (-)
BALB/cJ MGP_BALBcJ_G0018354
 protein coding gene Chr11:58158173-58286070 (-)
C3H/HeJ MGP_C3HHeJ_G0018167
 protein coding gene Chr11:59617496-59752279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018806
 protein coding gene Chr11:61994670-62129350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016452
 protein coding gene Chr11:55055244-55177091 (-)
CAST/EiJ MGP_CASTEiJ_G0017724
 protein coding gene Chr11:59757965-59894365 (-)
CBA/J MGP_CBAJ_G0018141
 protein coding gene Chr11:64720604-64860571 (-)
DBA/2J MGP_DBA2J_G0018250
 protein coding gene Chr11:57468106-57597569 (-)
FVB/NJ MGP_FVBNJ_G0018241
 protein coding gene Chr11:57137097-57265169 (-)
LP/J MGP_LPJ_G0018323
 protein coding gene Chr11:60699221-60830393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018265
 protein coding gene Chr11:65784880-65916858 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018847
 protein coding gene Chr11:59777502-59906146 (-)
PWK/PhJ MGP_PWKPhJ_G0017495
 protein coding gene Chr11:58073637-58202704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017287
 protein coding gene Chr11:59573063-59709953 (-)
WSB/EiJ MGP_WSBEiJ_G0017775
 protein coding gene Chr11:59451948-59585483 (-)



Homology
more
  • Human Ortholog
    TOM1L2, target of myb1 like 2 membrane trafficking protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOM1L2, target of myb1 like 2 membrane trafficking protein
  • Links
    NCBI Gene ID: 146691
    neXtProt AC: NX_Q6ZVM7
    UniProt: Q6ZVM7

  • Chr Location
    17p11.2; chr17:17843507-17972422 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 1 allele in 1 genetic background
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele show malocclusion, kyphosis, hydrocephaly, patchy hair, splenomegaly, high B- and T-cell counts, thrombopenia, impaired humoral responses, a high frequency of infections and tumors, renal cysts, skin lesions, freezing behavior and sporadic bleeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000538 Ensembl Gene Model | MGI Sequence Detail 126192 C57BL/6J ±  kb
    transcript ENSMUST00000102683 Ensembl | MGI Sequence Detail 4999 Not Applicable  
    polypeptide ENSMUSP00000099744 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920186, MGI:2144430
    References
    more
    • Summaries
      All 48
      Diseases 3
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345544 Shinde SR, et al., The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia. Dev Cell. 2023 Apr 24;58(8):677-693.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory