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Lax1 Gene Detail
Summary
  • Symbol
    Lax1
  • Name
    lymphocyte transmembrane adaptor 1
  • Synonyms
    E430019B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443362
    NCBI Gene: 240754
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:133606829-133617846 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.95 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443362
 protein coding gene Chr1:133606767-133620760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016492
 protein coding gene Chr1:137285509-137298238 (-)
A/J MGP_AJ_G0016475
 protein coding gene Chr1:132138585-132149593 (-)
AKR/J MGP_AKRJ_G0016440
 protein coding gene Chr1:136072871-136083856 (-)
BALB/cJ MGP_BALBcJ_G0016435
 protein coding gene Chr1:132472760-132483706 (-)
C3H/HeJ MGP_C3HHeJ_G0016261
 protein coding gene Chr1:136170444-136181449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016896
 protein coding gene Chr1:142312664-142323681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014607
 protein coding gene Chr1:125287942-125298925 (-)
CAST/EiJ MGP_CASTEiJ_G0015841
 protein coding gene Chr1:135209333-135220298 (-)
CBA/J MGP_CBAJ_G0016234
 protein coding gene Chr1:147198184-147209062 (-)
DBA/2J MGP_DBA2J_G0016340
 protein coding gene Chr1:131154218-131165926 (-)
FVB/NJ MGP_FVBNJ_G0016339
 protein coding gene Chr1:129773750-129785178 (-)
LP/J MGP_LPJ_G0016411
 protein coding gene Chr1:138563402-138574403 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016364
 protein coding gene Chr1:152954627-152967222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016932
 protein coding gene Chr1:135792385-135805248 (-)
PWK/PhJ MGP_PWKPhJ_G0015627
 protein coding gene Chr1:130157406-130168761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015414
 protein coding gene Chr1:134765298-134776101 (-)
WSB/EiJ MGP_WSBEiJ_G0015904
 protein coding gene Chr1:135817748-135828772 (-)



Homology
more
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
  • Synonyms
    LAX
  • Links
    NCBI Gene ID: 54900
    neXtProt AC: NX_Q8IWV1
    UniProt: Q8IWV1

  • Chr Location
    1q32.1; chr1:203765177-203776372 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051998 Ensembl Gene Model | MGI Sequence Detail 11018 C57BL/6J ±  kb
    transcript ENSMUST00000169295 Ensembl | MGI Sequence Detail 2309 Not Applicable  
    polypeptide ENSMUSP00000131126 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:126552 Sancho-Shimizu V, et al., Molecular genetic analysis of two Loci (ity2 and ity3) involved in the host response to infection with salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007 Oct;177(2):1125-39
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory