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Foxj3 Gene Detail
Summary
  • Symbol
    Foxj3
  • Name
    forkhead box J3
  • Synonyms
    C330039G02Rik, Fhd6, mKIAA1041
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443432
    NCBI Gene: 230700
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119396858-119486316 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1773 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443432
 protein coding gene Chr4:119394201-119486316 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028702
 protein coding gene Chr4:120740175-120838749 (+)
A/J MGP_AJ_G0028662
 protein coding gene Chr4:115999099-116090788 (+)
AKR/J MGP_AKRJ_G0028615
 protein coding gene Chr4:118516344-118622780 (+)
BALB/cJ MGP_BALBcJ_G0028685
 protein coding gene Chr4:116629970-116720974 (+)
C3H/HeJ MGP_C3HHeJ_G0028400
 protein coding gene Chr4:120082397-120180894 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029126
 protein coding gene Chr4:125322062-125426116 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026403
 protein coding gene Chr4:110089659-110185941 (+)
CAST/EiJ MGP_CASTEiJ_G0027831
 protein coding gene Chr4:117406765-117502516 (+)
CBA/J MGP_CBAJ_G0028367
 protein coding gene Chr4:128721236-128823577 (+)
DBA/2J MGP_DBA2J_G0028514
 protein coding gene Chr4:116586472-116679430 (+)
FVB/NJ MGP_FVBNJ_G0028480
 protein coding gene Chr4:115104476-115197909 (+)
LP/J MGP_LPJ_G0028614
 protein coding gene Chr4:120862928-120964472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028508
 protein coding gene Chr4:133598963-133709819 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029163
 protein coding gene Chr4:119592969-119690451 (+)
PWK/PhJ MGP_PWKPhJ_G0027554
 protein coding gene Chr4:113512601-113609539 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027380
 protein coding gene Chr4:116005087-116103837 (+)
WSB/EiJ MGP_WSBEiJ_G0027911
 protein coding gene Chr4:119600737-119701797 (+)



Homology
more
  • Human Ortholog
    FOXJ3, forkhead box J3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXJ3, forkhead box J3
  • Links
    NCBI Gene ID: 22887
    neXtProt AC: NX_Q9UPW0
    UniProt: Q9UPW0

  • Chr Location
    1p34.2; chr1:42176539-42335880 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have an abnormal skeletal muscle fiber type ratio in males as well as defects in muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1002
  • Tissues
    222
  • cDNA Data
    76
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230700 NCBI Gene Model | MGI Sequence Detail 89459 C57BL/6J ±  kb
    transcript NM_001357177 RefSeq | MGI Sequence Detail 5677 C57BL/6  
    polypeptide Q8BUR3 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 76
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:891992
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:39656 Farrington SM, et al., Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech Dev. 1997 Mar;62(2):197-211
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory