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Cemip Gene Detail
Summary
  • Symbol
    Cemip
  • Name
    cell migration inducing protein, hyaluronan binding
  • Synonyms
    12H19.01.T7, 6330404C01Rik, 9930013L23Rik, Hybid
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443629
    NCBI Gene: 80982
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:83582065-83735710 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443629
 protein coding gene Chr7:83582065-83735893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032456
 protein coding gene Chr7:86108400-86266100 (-)
A/J MGP_AJ_G0032433
 protein coding gene Chr7:84022330-84177188 (-)
AKR/J MGP_AKRJ_G0032370
 protein coding gene Chr7:85950654-86112750 (-)
BALB/cJ MGP_BALBcJ_G0032446
 protein coding gene Chr7:83688553-83846636 (-)
C3H/HeJ MGP_C3HHeJ_G0032160
 protein coding gene Chr7:86511611-86674513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032937
 protein coding gene Chr7:89426685-89595178 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029945
 protein coding gene Chr7:86379734-86530349 (-)
CAST/EiJ MGP_CASTEiJ_G0031486
 protein coding gene Chr7:77474401-77637776 (-)
CBA/J MGP_CBAJ_G0032125
 protein coding gene Chr7:92435348-92606714 (-)
DBA/2J MGP_DBA2J_G0032280
 protein coding gene Chr7:82527584-82681182 (-)
FVB/NJ MGP_FVBNJ_G0032234
 protein coding gene Chr7:82481805-82632982 (-)
LP/J MGP_LPJ_G0032361
 protein coding gene Chr7:87356339-87515475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032271
 protein coding gene Chr7:92472911-92627593 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032957
 protein coding gene Chr7:85351473-85508473 (-)
PWK/PhJ MGP_PWKPhJ_G0031207
 protein coding gene Chr7:75754774-75930197 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031049
 protein coding gene Chr7:72332963-72494603 (-)
WSB/EiJ MGP_WSBEiJ_G0031603
 protein coding gene Chr7:85722914-85881824 (-)



Homology
more
  • Human Ortholog
    CEMIP, cell migration inducing hyaluronidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEMIP, cell migration inducing hyaluronidase 1
  • Synonyms
    CCSP1, CEMIP1, HYBID, KIAA1199, TMEM2L
  • Links
    NCBI Gene ID: 57214
    neXtProt AC: NX_Q8WUJ3
    UniProt: Q8WUJ3

  • Chr Location
    15q25.1; chr15:80779343-80951776 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Schwann cells exhibit transient acceleration of postnatal myelination, reduced demyelination in culture, and reduced myelin degradation and increases remyelination following nerve axotomy or sciatic nerve crush. Mice homozygous for a null allele exhibit incomplete prenatal lethality, decreased osteoclast cell number, decreased angiogenesis, increased long bone epiphyseal plate size, and short long bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    44
  • cDNA Data
    20
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052353 Ensembl Gene Model | MGI Sequence Detail 153646 C57BL/6J ±  kb
    transcript ENSMUST00000064174 Ensembl | MGI Sequence Detail 7111 Not Applicable  
    polypeptide ENSMUSP00000063277 Ensembl | MGI Sequence Detail 1361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917968, MGI:1931098
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:335320 Chen L, et al., KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration. Nat Commun. 2023 Apr 10;14(1):2016
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory