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Pou6f2 Gene Detail
Summary
  • Symbol
    Pou6f2
  • Name
    POU domain, class 6, transcription factor 2
  • Synonyms
    D130006K24Rik, RPF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443631
    NCBI Gene: 218030
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:18295683-18572271 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 6.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8070 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443631
 protein coding gene Chr13:18295683-18797703 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020255
 protein coding gene Chr13:15202808-15473035 (-)
A/J MGP_AJ_G0020212
 protein coding gene Chr13:15006114-15283012 (-)
AKR/J MGP_AKRJ_G0020186
 protein coding gene Chr13:15186267-15459385 (-)
BALB/cJ MGP_BALBcJ_G0020198
 protein coding gene Chr13:14974472-15363928 (-)
C3H/HeJ MGP_C3HHeJ_G0020001
 protein coding gene Chr13:15305701-15695475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020642
 protein coding gene Chr13:15886943-16275520 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018249
 protein coding gene Chr13:13486651-13754563 (-)
CAST/EiJ MGP_CASTEiJ_G0019536
 protein coding gene Chr13:15024469-15320142 (-)
CBA/J MGP_CBAJ_G0019965
 protein coding gene Chr13:16411872-16816913 (-)
DBA/2J MGP_DBA2J_G0020084
 protein coding gene Chr13:14594194-14855997 (-)
FVB/NJ MGP_FVBNJ_G0020066
 protein coding gene Chr13:14296604-14565679 (-)
LP/J MGP_LPJ_G0020155
 protein coding gene Chr13:15475560-15756196 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020104
 protein coding gene Chr13:16773901-17178784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020671
 protein coding gene Chr13:15010630-15278464 (-)
PWK/PhJ MGP_PWKPhJ_G0019299
 protein coding gene Chr13:14642566-15036171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019105
 protein coding gene Chr13:14146074-14418826 (-)
WSB/EiJ MGP_WSBEiJ_G0019595
 protein coding gene Chr13:15031150-15420922 (-)



Homology
more
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Synonyms
    RPF-1, WT5, WTSL
  • Links
    NCBI Gene ID: 11281
    neXtProt AC: NX_P78424
    UniProt: P78424

  • Chr Location
    7p14.1; chr7:38977909-39493095 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POU6F2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    54
  • cDNA Data
    10
  • Literature Summary
    16
Sequences &
Gene Models
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  • All Sequences
    63
  • RefSeq
    19
  • UniProt
    6
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009734 Ensembl Gene Model | MGI Sequence Detail 276589 C57BL/6J ±  kb
transcript ENSMUST00000139064 Ensembl | MGI Sequence Detail 5977 Not Applicable  
polypeptide ENSMUSP00000114173 Ensembl | MGI Sequence Detail 637 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 47
    Developmental Gene Expression 16
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:341711 Zhou H, et al., Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. J Neurosci. 1996 Apr 1;16(7):2261-74
  • Latest
    J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory