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Slc12a8 Gene Detail
Summary
  • Symbol
    Slc12a8
  • Name
    solute carrier family 12 (potassium/chloride transporters), member 8
  • Synonyms
    E330020C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443672
    NCBI Gene: 171286
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33337698-33484505 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4517 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443672
 protein coding gene Chr16:33337440-33484508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022756
 protein coding gene Chr16:31729844-31879451 (+)
A/J MGP_AJ_G0022721
 protein coding gene Chr16:30206566-30350595 (+)
AKR/J MGP_AKRJ_G0022694
 protein coding gene Chr16:31274471-31421111 (+)
BALB/cJ MGP_BALBcJ_G0022723
 protein coding gene Chr16:30315588-30461800 (+)
C3H/HeJ MGP_C3HHeJ_G0022488
 protein coding gene Chr16:31398460-31549495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023172
 protein coding gene Chr16:32425655-32585204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020690
 protein coding gene Chr16:30543417-30695708 (+)
CAST/EiJ MGP_CASTEiJ_G0022016
 protein coding gene Chr16:31564468-31727361 (+)
CBA/J MGP_CBAJ_G0022458
 protein coding gene Chr16:33725688-33885825 (+)
DBA/2J MGP_DBA2J_G0022591
 protein coding gene Chr16:30022476-30175038 (+)
FVB/NJ MGP_FVBNJ_G0022566
 protein coding gene Chr16:30016663-30165814 (+)
LP/J MGP_LPJ_G0022658
 protein coding gene Chr16:31462575-31613555 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022585
 protein coding gene Chr16:33113215-33268823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023184
 protein coding gene Chr16:31277141-31428912 (+)
PWK/PhJ MGP_PWKPhJ_G0021757
 protein coding gene Chr16:30408833-30548742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021586
 protein coding gene Chr16:31063172-31218420 (+)
WSB/EiJ MGP_WSBEiJ_G0022060
 protein coding gene Chr16:31241579-31393629 (+)



Homology
more
  • Human Ortholog
    SLC12A8, solute carrier family 12 member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC12A8, solute carrier family 12 member 8
  • Synonyms
    CCC9
  • Links
    NCBI Gene ID: 84561
    neXtProt AC: NX_A0AV02
    UniProt: A0AV02

  • Chr Location
    3q21.2; chr3:125082636-125212864 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some prenatal lethality and reduced NAD+ levels in the jejunum and ileum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    130
  • cDNA Data
    30
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035506 Ensembl Gene Model | MGI Sequence Detail 146808 C57BL/6J ±  kb
transcript ENSMUST00000059056 Ensembl | MGI Sequence Detail 3166 Not Applicable  
polypeptide ENSMUSP00000062337 Ensembl | MGI Sequence Detail 705 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:333074 Ito N, et al., Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Cell Rep. 2022 Jul 26;40(4):111131
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory