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Bnc2 Gene Detail
Summary
  • Symbol
    Bnc2
  • Name
    basonuclin zinc finger protein 2
  • Synonyms
    5031434M05Rik, 8430420F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443805
    NCBI Gene: 242509
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:84193332-84593512 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443805
 protein coding gene Chr4:84185041-84593512 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028406
 protein coding gene Chr4:83890239-84307567 (-)
A/J MGP_AJ_G0028367
 protein coding gene Chr4:80982437-81386845 (-)
AKR/J MGP_AKRJ_G0028316
 protein coding gene Chr4:83079451-83490591 (-)
BALB/cJ MGP_BALBcJ_G0028387
 protein coding gene Chr4:81209216-81618058 (-)
C3H/HeJ MGP_C3HHeJ_G0028102
 protein coding gene Chr4:83693754-84101965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028826
 protein coding gene Chr4:87195764-87604177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026126
 protein coding gene Chr4:76937009-77334759 (-)
CAST/EiJ MGP_CASTEiJ_G0027543
 protein coding gene Chr4:81607590-82012935 (-)
CBA/J MGP_CBAJ_G0028071
 protein coding gene Chr4:89852412-90271285 (-)
DBA/2J MGP_DBA2J_G0028220
 protein coding gene Chr4:80768861-81175004 (-)
FVB/NJ MGP_FVBNJ_G0028186
 protein coding gene Chr4:79768461-80170109 (-)
LP/J MGP_LPJ_G0028320
 protein coding gene Chr4:84260590-84667385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028215
 protein coding gene Chr4:94960638-95393457 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028863
 protein coding gene Chr4:83134496-83548434 (-)
PWK/PhJ MGP_PWKPhJ_G0027266
 protein coding gene Chr4:79118932-79526642 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027091
 protein coding gene Chr4:80696291-81115221 (-)
WSB/EiJ MGP_WSBEiJ_G0027619
 protein coding gene Chr4:83308092-83716851 (-)



Homology
more
  • Human Ortholog
    BNC2, basonuclin zinc finger protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BNC2, basonuclin zinc finger protein 2
  • Synonyms
    bn2, BSN2, LUTO
  • Links
    NCBI Gene ID: 54796
    neXtProt AC: NX_Q6ZN30
    UniProt: Q6ZN30

  • Chr Location
    9p22.3-p22.2; chr9:16409503-16870843 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion die within 24 hrs of birth and display cleft palate, an overall size reduction of the head and tongue, and abnormal craniofacial bone development due to impaired multiplication of embryonic craniofacial mesenchymal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    97
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028487 Ensembl Gene Model | MGI Sequence Detail 400181 C57BL/6J ±  kb
    transcript ENSMUST00000102820 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000099884 Ensembl | MGI Sequence Detail 1127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 18
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918748
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory