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Osbpl8 Gene Detail
Summary
  • Symbol
    Osbpl8
  • Name
    oxysterol binding protein-like 8
  • Synonyms
    D330025H14Rik, ORP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443807
    NCBI Gene: 237542
  • Alliance
    gene page
  • Transcription Start Sites
    57 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:111000663-111133110 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 58.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3500 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443807
 protein coding gene Chr10:111000613-111133110 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017719
 protein coding gene Chr10:113557935-113692225 (+)
A/J MGP_AJ_G0017696
 protein coding gene Chr10:109245198-109377474 (+)
AKR/J MGP_AKRJ_G0017658
 protein coding gene Chr10:112481743-112574556 (+)
BALB/cJ MGP_BALBcJ_G0017660
 protein coding gene Chr10:109683609-109778469 (+)
C3H/HeJ MGP_C3HHeJ_G0017485
 protein coding gene Chr10:112577400-112716521 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018117
 protein coding gene Chr10:117483064-117621846 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015796
 protein coding gene Chr10:104101920-104240958 (+)
CAST/EiJ MGP_CASTEiJ_G0017046
 protein coding gene Chr10:112739187-112878547 (+)
CBA/J MGP_CBAJ_G0017454
 protein coding gene Chr10:122094006-122240272 (+)
DBA/2J MGP_DBA2J_G0017559
 protein coding gene Chr10:108384116-108522122 (+)
FVB/NJ MGP_FVBNJ_G0017553
 protein coding gene Chr10:107375650-107508466 (+)
LP/J MGP_LPJ_G0017633
 protein coding gene Chr10:114198765-114346402 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017582
 protein coding gene Chr10:124751245-124882488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018155
 protein coding gene Chr10:112459025-112594841 (+)
PWK/PhJ MGP_PWKPhJ_G0016828
 protein coding gene Chr10:108457941-108598089 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016618
 protein coding gene Chr10:111208584-111345039 (+)
WSB/EiJ MGP_WSBEiJ_G0017106
 protein coding gene Chr10:112592173-112731468 (+)



Homology
more
  • Human Ortholog
    OSBPL8, oxysterol binding protein like 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSBPL8, oxysterol binding protein like 8
  • Synonyms
    MST120, MSTP120, ORP8, OSBP10
  • Links
    NCBI Gene ID: 114882
    neXtProt AC: NX_Q9BZF1
    UniProt: Q9BZF1

  • Chr Location
    12q21.2; chr12:76351797-76559809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit elevated of HDL and gender-specific alterations in lipid metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237542 NCBI Gene Model | MGI Sequence Detail 132448 C57BL/6J ±  kb
    transcript NM_175489 RefSeq | MGI Sequence Detail 7152 Not Specified  
    polypeptide B9EJ86 UniProt | EBI | MGI Sequence Detail 889 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012053 oxysterol-binding protein-related protein 8
      (term hierarchy)
    • InterPro Domains
      IPR000648 Oxysterol-binding protein
      IPR018494 Oxysterol-binding protein, conserved site
      IPR037239 Oxysterol-binding protein superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
    • GlyGen
      B9EJ86 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143486, MGI:2143487, MGI:2443126
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory