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Arhgap29 Gene Detail
Summary
  • Symbol
    Arhgap29
  • Name
    Rho GTPase activating protein 29
  • Synonyms
    6720461J18Rik, B130017I01Rik, C76601, Parg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443818
    NCBI Gene: 214137
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:121746752-121810326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 52.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443818
 protein coding gene Chr3:121746190-121810402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027835
 protein coding gene Chr3:124175430-124243589 (+)
A/J MGP_AJ_G0027793
 protein coding gene Chr3:120037687-120101896 (+)
AKR/J MGP_AKRJ_G0027759
 protein coding gene Chr3:123089694-123156725 (+)
BALB/cJ MGP_BALBcJ_G0027805
 protein coding gene Chr3:119843746-119909312 (+)
C3H/HeJ MGP_C3HHeJ_G0027536
 protein coding gene Chr3:123486428-123552058 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028251
 protein coding gene Chr3:128665081-128731176 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025590
 protein coding gene Chr3:115453557-115519975 (+)
CAST/EiJ MGP_CASTEiJ_G0026992
 protein coding gene Chr3:122862979-122932922 (+)
CBA/J MGP_CBAJ_G0027511
 protein coding gene Chr3:133046895-133118355 (+)
DBA/2J MGP_DBA2J_G0027652
 protein coding gene Chr3:119180426-119245479 (+)
FVB/NJ MGP_FVBNJ_G0027620
 protein coding gene Chr3:116781942-116849094 (+)
LP/J MGP_LPJ_G0027762
 protein coding gene Chr3:125699087-125770564 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027650
 protein coding gene Chr3:140630277-140698335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028307
 protein coding gene Chr3:122644288-122709863 (+)
PWK/PhJ MGP_PWKPhJ_G0026718
 protein coding gene Chr3:118879442-118945310 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026541
 protein coding gene Chr3:120737911-120811204 (+)
WSB/EiJ MGP_WSBEiJ_G0027072
 protein coding gene Chr3:123363350-123435230 (+)



Homology
more
  • Human Ortholog
    ARHGAP29, Rho GTPase activating protein 29
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP29, Rho GTPase activating protein 29
  • Synonyms
    PARG1
  • Links
    NCBI Gene ID: 9411
    neXtProt AC: NX_Q52LW3
    UniProt: Q52LW3

  • Chr Location
    1p22.1-p21.3; chr1:94148988-94314592 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in complete embryonic lethality between implantation and placentation. Heterozygotes show abnormal oral epithelial adhesions during embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    27
  • cDNA Data
    152
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214137 NCBI Gene Model | MGI Sequence Detail 63575 C57BL/6J ±  kb
    transcript NM_172525 RefSeq | MGI Sequence Detail 5711 C57BL/6  
    polypeptide Q8CGF1 UniProt | EBI | MGI Sequence Detail 1266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 153
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1924435, MGI:2139903, MGI:2140040
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory