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Ccar2 Gene Detail
Summary
  • Symbol
    Ccar2
  • Name
    cell cycle activator and apoptosis regulator 2
  • Synonyms
    2610301G19Rik, Dbc1, mKIAA1967
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444228
    NCBI Gene: 219158
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70375613-70391260 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444228
 protein coding gene Chr14:70375613-70391272 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021530
 protein coding gene Chr14:64759342-64775007 (-)
A/J MGP_AJ_G0021489
 protein coding gene Chr14:63401426-63417055 (-)
AKR/J MGP_AKRJ_G0021465
 protein coding gene Chr14:65301222-65316856 (-)
BALB/cJ MGP_BALBcJ_G0021495
 protein coding gene Chr14:63161627-63177261 (-)
C3H/HeJ MGP_C3HHeJ_G0021272
 protein coding gene Chr14:65013894-65029528 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021934
 protein coding gene Chr14:67676019-67693090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019474
 protein coding gene Chr14:61238765-61254296 (-)
CAST/EiJ MGP_CASTEiJ_G0020789
 protein coding gene Chr14:61598026-61613686 (-)
CBA/J MGP_CBAJ_G0021239
 protein coding gene Chr14:69790696-69806330 (-)
DBA/2J MGP_DBA2J_G0021362
 protein coding gene Chr14:62782862-62798690 (-)
FVB/NJ MGP_FVBNJ_G0021341
 protein coding gene Chr14:62211275-62226909 (-)
LP/J MGP_LPJ_G0021433
 protein coding gene Chr14:66012313-66027981 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021370
 protein coding gene Chr14:68706158-68721826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021958
 protein coding gene Chr14:64565174-64580803 (-)
PWK/PhJ MGP_PWKPhJ_G0020533
 protein coding gene Chr14:59544799-59560700 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020366
 protein coding gene Chr14:60488063-60505023 (-)
WSB/EiJ MGP_WSBEiJ_G0020842
 protein coding gene Chr14:64870388-64886896 (-)



Homology
more
  • Human Ortholog
    CCAR2, cell cycle and apoptosis regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCAR2, cell cycle and apoptosis regulator 2
  • Synonyms
    DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
  • Links
    NCBI Gene ID: 57805
    neXtProt AC: NX_Q8N163
    UniProt: Q8N163

  • Chr Location
    8p21.3; chr8:22604757-22621514 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice on a high fat diet are resistant to hepatic steatosis and associated liver inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    9
  • cDNA Data
    71
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033712 Ensembl Gene Model | MGI Sequence Detail 15648 C57BL/6J ±  kb
    transcript ENSMUST00000035612 Ensembl | MGI Sequence Detail 3725 Not Applicable  
    polypeptide ENSMUSP00000036924 Ensembl | MGI Sequence Detail 922 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 72

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory