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Arhgef10 Gene Detail
Summary
  • Symbol
    Arhgef10
  • Name
    Rho guanine nucleotide exchange factor 10
  • Synonyms
    6430549H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444453
    NCBI Gene: 234094
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:14961663-15051085 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 7.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3094 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444453
 protein coding gene Chr8:14956405-15051085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033398
 protein coding gene Chr8:12332872-12429496 (+)
A/J MGP_AJ_G0033379
 protein coding gene Chr8:11905277-11998171 (+)
AKR/J MGP_AKRJ_G0033309
 protein coding gene Chr8:12203218-12295369 (+)
BALB/cJ MGP_BALBcJ_G0033379
 protein coding gene Chr8:11980832-12070824 (+)
C3H/HeJ MGP_C3HHeJ_G0033092
 protein coding gene Chr8:12427086-12523336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033891
 protein coding gene Chr8:12700877-12803798 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030857
 protein coding gene Chr8:11305018-11396863 (+)
CAST/EiJ MGP_CASTEiJ_G0032414
 protein coding gene Chr8:12237808-12336750 (+)
CBA/J MGP_CBAJ_G0033065
 protein coding gene Chr8:13256364-13352191 (+)
DBA/2J MGP_DBA2J_G0033219
 protein coding gene Chr8:11818351-11907888 (+)
FVB/NJ MGP_FVBNJ_G0033167
 protein coding gene Chr8:11843715-11939388 (+)
LP/J MGP_LPJ_G0033312
 protein coding gene Chr8:12306468-12404052 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033204
 protein coding gene Chr8:13465402-13566205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033908
 protein coding gene Chr8:12286381-12376703 (+)
PWK/PhJ MGP_PWKPhJ_G0032127
 protein coding gene Chr8:11881281-11973867 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031968
 protein coding gene Chr8:12159720-12257809 (+)
WSB/EiJ MGP_WSBEiJ_G0032530
 protein coding gene Chr8:12308547-12409342 (+)



Homology
more
  • Human Ortholog
    ARHGEF10, Rho guanine nucleotide exchange factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF10, Rho guanine nucleotide exchange factor 10
  • Synonyms
    GEF10, SNCV
  • Links
    NCBI Gene ID: 9639
    neXtProt AC: NX_O15013
    UniProt: O15013

  • Chr Location
    8p23.3; chr8:1823300-1958641 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arhgef10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit social deficits, hyperactivity, reduced anxiety-like and depression-like behavior, and increased serotonin, norepinephrine, and dopamine levels in different brain regions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    62
  • cDNA Data
    77
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071176 Ensembl Gene Model | MGI Sequence Detail 89423 C57BL/6J ±  kb
    transcript ENSMUST00000084207 Ensembl | MGI Sequence Detail 5528 Not Applicable  
    polypeptide ENSMUSP00000081225 Ensembl | MGI Sequence Detail 1345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004246 Rho guanine nucleotide exchange factor 10
      (term hierarchy)
    • InterPro Domains
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR039919 Rho guanine nucleotide exchange factor 10/17
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q8C033 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 77
      Primer pair 3
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory