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Dmxl2 Gene Detail
Summary
  • Symbol
    Dmxl2
  • Name
    Dmx-like 2
  • Synonyms
    6430411K14Rik, E130119P06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444630
    NCBI Gene: 235380
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54272442-54408910 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.58 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444630
 protein coding gene Chr9:54272442-54409150 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034823
 protein coding gene Chr9:53402652-53544172 (-)
A/J MGP_AJ_G0034804
 protein coding gene Chr9:51700602-51839582 (-)
AKR/J MGP_AKRJ_G0034732
 protein coding gene Chr9:52866199-53012603 (-)
BALB/cJ MGP_BALBcJ_G0034796
 protein coding gene Chr9:51470670-51613559 (-)
C3H/HeJ MGP_C3HHeJ_G0034506
 protein coding gene Chr9:53336779-53478437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035315
 protein coding gene Chr9:54889808-55046218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032227
 protein coding gene Chr9:51110858-51252654 (-)
CAST/EiJ MGP_CASTEiJ_G0033828
 protein coding gene Chr9:53344846-53491859 (-)
CBA/J MGP_CBAJ_G0034477
 protein coding gene Chr9:56774589-56938785 (-)
DBA/2J MGP_DBA2J_G0034636
 protein coding gene Chr9:51589815-51727911 (-)
FVB/NJ MGP_FVBNJ_G0034578
 protein coding gene Chr9:50789160-50925861 (-)
LP/J MGP_LPJ_G0034718
 protein coding gene Chr9:53712975-53865416 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034621
 protein coding gene Chr9:58356163-58506674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035337
 protein coding gene Chr9:52865891-53014171 (-)
PWK/PhJ MGP_PWKPhJ_G0033532
 protein coding gene Chr9:51560445-51703747 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033367
 protein coding gene Chr9:53138413-53289276 (-)
WSB/EiJ MGP_WSBEiJ_G0033940
 protein coding gene Chr9:52848181-52992591 (-)



Homology
more
  • Human Ortholog
    DMXL2, Dmx like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMXL2, Dmx like 2
  • Synonyms
    DEE81, DFNA71, EIEE81, PEPNS, RC3
  • Links
    NCBI Gene ID: 23312
    neXtProt AC: NX_Q8TDJ6
    UniProt: Q8TDJ6

  • Chr Location
    15q21.2
Human Diseases
more
  • Diseases
    2 with human DMXL2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    13
  • cDNA Data
    78
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041268 Ensembl Gene Model | MGI Sequence Detail 136469 C57BL/6J ±  kb
    transcript ENSMUST00000118163 Ensembl | MGI Sequence Detail 10614 Not Applicable  
    polypeptide ENSMUSP00000113705 Ensembl | MGI Sequence Detail 3054 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006553 DmX-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR052208 DmX-like/RAVE complex component
      IPR022033 RAVE complex protein Rav1 C-terminal
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q8BPN8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924131
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory