About   Help   FAQ
Sptlc3 Gene Detail
Summary
  • Symbol
    Sptlc3
  • Name
    serine palmitoyltransferase, long chain base subunit 3
  • Synonyms
    C130053K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444678
    NCBI Gene: 228677
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:139335833-139478981 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 68.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444678
 protein coding gene Chr2:139335833-139479594 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026564
 protein coding gene Chr2:143380135-143539731 (+)
A/J MGP_AJ_G0026528
 protein coding gene Chr2:137600395-137740575 (+)
AKR/J MGP_AKRJ_G0026502
 protein coding gene Chr2:141525124-141674881 (+)
BALB/cJ MGP_BALBcJ_G0026540
 protein coding gene Chr2:137978654-138125475 (+)
C3H/HeJ MGP_C3HHeJ_G0026283
 protein coding gene Chr2:142008345-142179717 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026985
 protein coding gene Chr2:147692204-147846492 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024362
 protein coding gene Chr2:131930493-132057482 (+)
CAST/EiJ MGP_CASTEiJ_G0025744
 protein coding gene Chr2:142332773-142477792 (+)
CBA/J MGP_CBAJ_G0026263
 protein coding gene Chr2:153100496-153263577 (+)
DBA/2J MGP_DBA2J_G0026397
 protein coding gene Chr2:136917762-137066409 (+)
FVB/NJ MGP_FVBNJ_G0026361
 protein coding gene Chr2:135493032-135628714 (+)
LP/J MGP_LPJ_G0026501
 protein coding gene Chr2:143529928-143672406 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026381
 protein coding gene Chr2:157088138-157261112 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027040
 protein coding gene Chr2:141499613-141641014 (+)
PWK/PhJ MGP_PWKPhJ_G0025480
 protein coding gene Chr2:136501941-136647021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025282
 protein coding gene Chr2:140563395-140715325 (+)
WSB/EiJ MGP_WSBEiJ_G0025818
 protein coding gene Chr2:142463722-142615301 (+)



Homology
more
  • Human Ortholog
    SPTLC3, serine palmitoyltransferase long chain base subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPTLC3, serine palmitoyltransferase long chain base subunit 3
  • Synonyms
    C20orf38, dJ718P11, dJ718P11.1, hLCB2b, LCB2B, LCB 3, LCB3, SPT 3, SPT3, SPTLC2L
  • Links
    NCBI Gene ID: 55304
    neXtProt AC: NX_Q9NUV7
    UniProt: Q9NUV7

  • Chr Location
    chr20:13008972-13169103 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    114
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228677 NCBI Gene Model | MGI Sequence Detail 143149 C57BL/6J ±  kb
    transcript NM_001356507 RefSeq | MGI Sequence Detail 2232 C57BL/6  
    polypeptide Q8BG54 UniProt | EBI | MGI Sequence Detail 563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015598 serine palmitoyltransferase 3
      (term hierarchy)
    • EC
      2.3.1.50
    • InterPro Domains
      IPR050087 8-amino-7-oxononanoate synthase class-II
      IPR004839 Aminotransferase, class I/classII
      IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory