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Prtg Gene Detail
Summary
  • Symbol
    Prtg
  • Name
    protogenin
  • Synonyms
    A230098A12Rik, Igdcc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444710
    NCBI Gene: 235472
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72714556-72824589 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2783 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444710
 protein coding gene Chr9:72714156-72824589 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035018
 protein coding gene Chr9:72997354-73118584 (+)
A/J MGP_AJ_G0034999
 protein coding gene Chr9:70454933-70562196 (+)
AKR/J MGP_AKRJ_G0034928
 protein coding gene Chr9:72144683-72255658 (+)
BALB/cJ MGP_BALBcJ_G0034991
 protein coding gene Chr9:70160890-70269738 (+)
C3H/HeJ MGP_C3HHeJ_G0034700
 protein coding gene Chr9:72632125-72744999 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035510
 protein coding gene Chr9:74921250-75038521 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032421
 protein coding gene Chr9:69934766-70038632 (+)
CAST/EiJ MGP_CASTEiJ_G0034022
 protein coding gene Chr9:72960069-73080375 (+)
CBA/J MGP_CBAJ_G0034673
 protein coding gene Chr9:77527817-77659777 (+)
DBA/2J MGP_DBA2J_G0034832
 protein coding gene Chr9:70172104-70278437 (+)
FVB/NJ MGP_FVBNJ_G0034774
 protein coding gene Chr9:69480037-69587900 (+)
LP/J MGP_LPJ_G0034913
 protein coding gene Chr9:73218381-73342938 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034815
 protein coding gene Chr9:78618735-78742332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035532
 protein coding gene Chr9:72287023-72406738 (+)
PWK/PhJ MGP_PWKPhJ_G0033726
 protein coding gene Chr9:70445186-70556042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033559
 protein coding gene Chr9:72579239-72695041 (+)
WSB/EiJ MGP_WSBEiJ_G0034134
 protein coding gene Chr9:72220766-72339366 (+)



Homology
more
  • Human Ortholog
    PRTG, protogenin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRTG, protogenin
  • Synonyms
    IGDCC5
  • Links
    NCBI Gene ID: 283659
    neXtProt AC: NX_Q2VWP7
    UniProt: Q2VWP7

  • Chr Location
    15q21.3; chr15:55611544-55743152 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial lethality within 72 hours of birth due to malnutrition from defective craniofacial structures including palatal bones and nasal septum. Further lethality is seen before P14, with mice showing growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 235472 NCBI Gene Model | MGI Sequence Detail 110034 C57BL/6J ±  kb
    transcript NM_175485 RefSeq | MGI Sequence Detail 8764 Not Specified  
    polypeptide Q2EY15 UniProt | EBI | MGI Sequence Detail 1191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 11
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:74152 Yamaza H, et al., Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Int J Dev Biol. 2001 Jun;45(4):675-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory