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Negr1 Gene Detail
Summary
  • Symbol
    Negr1
  • Name
    neuronal growth regulator 1
  • Synonyms
    5330422G01Rik, neurotractin, Ntra
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444846
    NCBI Gene: 320840
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:156267431-157022082 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 80.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    18904 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444846
 protein coding gene Chr3:156266082-157022101 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028010
 protein coding gene Chr3:160661031-161443754 (+)
A/J MGP_AJ_G0027968
 protein coding gene Chr3:154810306-155569071 (+)
AKR/J MGP_AKRJ_G0027934
 protein coding gene Chr3:158919037-159699733 (+)
BALB/cJ MGP_BALBcJ_G0027980
 protein coding gene Chr3:154613688-155364052 (+)
C3H/HeJ MGP_C3HHeJ_G0027710
 protein coding gene Chr3:159314312-160098457 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028423
 protein coding gene Chr3:165890080-166708329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025762
 protein coding gene Chr3:149441915-150201214 (+)
CAST/EiJ MGP_CASTEiJ_G0027163
 protein coding gene Chr3:159445280-160225725 (+)
CBA/J MGP_CBAJ_G0027685
 protein coding gene Chr3:171862043-172658676 (+)
DBA/2J MGP_DBA2J_G0027825
 protein coding gene Chr3:153852776-154609628 (+)
FVB/NJ MGP_FVBNJ_G0027792
 protein coding gene Chr3:151195436-151954598 (+)
LP/J MGP_LPJ_G0027936
 protein coding gene Chr3:161985741-162783413 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027825
 protein coding gene Chr3:180424117-181276057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028482
 protein coding gene Chr3:158594199-159375750 (+)
PWK/PhJ MGP_PWKPhJ_G0026886
 protein coding gene Chr3:153807726-154554440 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026714
 protein coding gene Chr3:156785531-157584404 (+)
WSB/EiJ MGP_WSBEiJ_G0027243
 protein coding gene Chr3:159583897-160347003 (+)



Homology
more
  • Human Ortholog
    NEGR1, neuronal growth regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEGR1, neuronal growth regulator 1
  • Synonyms
    DMML2433, IGLON4, KILON, Ntra
  • Links
    NCBI Gene ID: 257194
    neXtProt AC: NX_Q7Z3B1
    UniProt: Q7Z3B1

  • Chr Location
    1p31.1; chr1:71395943-72282539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or ENU-induced allele exhibit reduced body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    231
  • cDNA Data
    12
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040037 Ensembl Gene Model | MGI Sequence Detail 754652 C57BL/6J ±  kb
    transcript ENSMUST00000074015 Ensembl | MGI Sequence Detail 4983 Not Applicable  
    polypeptide ENSMUSP00000073664 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 12
      Primer pair 2
      Other 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 13
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:84972 Marg A, et al., Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 1999 May 17;145(4):865-76
    • Latest
      J:354852 Singh K, et al., The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024 Sep 30;14(1):22593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory