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Efr3b Gene Detail
Summary
  • Symbol
    Efr3b
  • Name
    EFR3 homolog B
  • Synonyms
    C030014M07Rik, mKIAA0953
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444851
    NCBI Gene: 668212
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4012554-4088915 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1965 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444851
 protein coding gene Chr12:4012554-4089199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019562
 protein coding gene Chr12:813271-894455 (-)
A/J MGP_AJ_G0019529
 protein coding gene Chr12:840399-916960 (-)
AKR/J MGP_AKRJ_G0019499
 protein coding gene Chr12:983007-1064073 (-)
BALB/cJ MGP_BALBcJ_G0019504
 protein coding gene Chr12:869874-945673 (-)
C3H/HeJ MGP_C3HHeJ_G0019310
 protein coding gene Chr12:767629-848210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019953
 protein coding gene Chr12:831984-912978 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017578
 protein coding gene Chr12:752776-829648 (-)
CAST/EiJ MGP_CASTEiJ_G0018865
 protein coding gene Chr12:830299-918723 (-)
CBA/J MGP_CBAJ_G0019281
 protein coding gene Chr12:1075214-1167011 (-)
DBA/2J MGP_DBA2J_G0019394
 protein coding gene Chr12:782573-858505 (-)
FVB/NJ MGP_FVBNJ_G0019384
 protein coding gene Chr12:809605-884224 (-)
LP/J MGP_LPJ_G0019465
 protein coding gene Chr12:831574-910067 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019418
 protein coding gene Chr12:882472-971456 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019992
 protein coding gene Chr12:768666-847340 (-)
PWK/PhJ MGP_PWKPhJ_G0018631
 protein coding gene Chr12:799443-876749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018422
 protein coding gene Chr12:846858-919601 (-)
WSB/EiJ MGP_WSBEiJ_G0018917
 protein coding gene Chr12:799693-878049 (-)



Homology
more
  • Human Ortholog
    EFR3B, EFR3 homolog B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFR3B, EFR3 homolog B
  • Synonyms
    KIAA0953
  • Links
    NCBI Gene ID: 22979
    neXtProt AC: NX_Q9Y2G0
    UniProt: Q9Y2G0

  • Chr Location
    2p23.3; chr2:25042076-25159135 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with conditional loss of expression in the brain display transient defects in social novelty recognition and pyramidal neuron function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    61
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020658 Ensembl Gene Model | MGI Sequence Detail 76362 C57BL/6J ±  kb
    transcript ENSMUST00000111178 Ensembl | MGI Sequence Detail 6547 Not Applicable  
    polypeptide ENSMUSP00000106809 Ensembl | MGI Sequence Detail 817 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144903
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory