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Miat Gene Detail
Summary
  • Symbol
    Miat
  • Name
    myocardial infarction associated transcript (non-protein coding)
  • Synonyms
    A230057G18Rik, gomafu, Rncr2
  • Feature Type
    lncRNA gene
  • IDs
    MGI:2444886
    NCBI Gene: 330166
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112361094-112376814 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 54.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444886
 lncRNA gene Chr5:112361094-112377261 (-)
129S1/SvImJ MGP_129S1SvImJ_G0006759
 lincRNA gene Chr5:114782039-114800128 (-)
A/J MGP_AJ_G0006753
 lincRNA gene Chr5:110314337-110331310 (-)
AKR/J MGP_AKRJ_G0006723
 lincRNA gene Chr5:113822369-113838419 (-)
BALB/cJ MGP_BALBcJ_G0006729
 lincRNA gene Chr5:111674694-111690842 (-)
C3H/HeJ MGP_C3HHeJ_G0006674
 lincRNA gene Chr5:114258273-114274833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0006894
 lincRNA gene Chr5:119269540-119285695 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006150
 lincRNA gene Chr5:105137761-105153843 (-)
CAST/EiJ MGP_CASTEiJ_G0006597
 lincRNA gene Chr5:113161282-113177374 (-)
CBA/J MGP_CBAJ_G0006656
 lincRNA gene Chr5:123745760-123764589 (-)
DBA/2J MGP_DBA2J_G0006676
 lincRNA gene Chr5:110380946-110397627 (-)
FVB/NJ MGP_FVBNJ_G0006700
 lincRNA gene Chr5:109101079-109117253 (-)
LP/J MGP_LPJ_G0006760
 lincRNA gene Chr5:115350456-115368988 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0006684
 lincRNA gene Chr5:128326559-128342703 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0006896
 lincRNA gene Chr5:113257008-113273173 (-)
PWK/PhJ MGP_PWKPhJ_G0006536
 lincRNA gene Chr5:108989145-109005344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0006442
 lincRNA gene Chr5:110735594-110753564 (-)
WSB/EiJ MGP_WSBEiJ_G0006648
 lincRNA gene Chr5:113767275-113784523 (-)



Homology
more
  • Human Ortholog
    MIAT, myocardial infarction associated transcript
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIAT, myocardial infarction associated transcript
  • Synonyms
    C22orf35, GOMAFU, LINC00066, lncRNA-MIAT, NCRNA00066, RNCR2
  • Links
    NCBI Gene ID: 440823

  • Chr Location
    22q12.1; chr22:26646411-26676478 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MIAT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity and an enhanced behavioral response to methamphetamine, associated with increased extracellular levels of dopamine in the nucleus accumbens after methamphetamine treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    49
  • cDNA Data
    8
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      52
    • RefSeq
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330166 NCBI Gene Model | MGI Sequence Detail 15721 C57BL/6J ±  kb
    transcript NR_033657 RefSeq | MGI Sequence Detail 8760 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 2
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory