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Tbck Gene Detail
Summary
  • Symbol
    Tbck
  • Name
    TBC1 domain containing kinase
  • Synonyms
    1700120J03Rik, A630047E20Rik, C030007I09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445052
    NCBI Gene: 271981
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:132389905-132547449 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4667 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445052
 protein coding gene Chr3:132389874-132547451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027893
 protein coding gene Chr3:135458612-135625103 (+)
A/J MGP_AJ_G0027851
 protein coding gene Chr3:130682184-130839998 (+)
AKR/J MGP_AKRJ_G0027816
 protein coding gene Chr3:134096049-134251809 (+)
BALB/cJ MGP_BALBcJ_G0027864
 protein coding gene Chr3:130514124-130670500 (+)
C3H/HeJ MGP_C3HHeJ_G0027593
 protein coding gene Chr3:134487137-134643053 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028307
 protein coding gene Chr3:140218105-140383424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025645
 protein coding gene Chr3:126122295-126271788 (+)
CAST/EiJ MGP_CASTEiJ_G0027049
 protein coding gene Chr3:134233584-134394745 (+)
CBA/J MGP_CBAJ_G0027569
 protein coding gene Chr3:144951724-145122990 (+)
DBA/2J MGP_DBA2J_G0027709
 protein coding gene Chr3:129853243-130005168 (+)
FVB/NJ MGP_FVBNJ_G0027676
 protein coding gene Chr3:127428745-127577355 (+)
LP/J MGP_LPJ_G0027819
 protein coding gene Chr3:136944975-137104081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027707
 protein coding gene Chr3:152918874-153091631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028365
 protein coding gene Chr3:133759907-133921552 (+)
PWK/PhJ MGP_PWKPhJ_G0026773
 protein coding gene Chr3:129612967-129772103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026598
 protein coding gene Chr3:131834214-131990533 (+)
WSB/EiJ MGP_WSBEiJ_G0027128
 protein coding gene Chr3:134523030-134681134 (+)



Homology
more
  • Human Ortholog
    TBCK, TBC1 domain containing kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBCK, TBC1 domain containing kinase
  • Synonyms
    FERRY1, Fy-1, HSPC302, IHPRF3, TBCKL
  • Links
    NCBI Gene ID: 93627
    neXtProt AC: NX_Q8TEA7
    UniProt: Q8TEA7

  • Chr Location
    4q24; chr4:106041599-106316683 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TBCK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are embryonic lethal. Heterozygotes exhibit reduced exploratory behavior often with sex-specific differences.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    31
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028030 Ensembl Gene Model | MGI Sequence Detail 157545 C57BL/6J ±  kb
    transcript ENSMUST00000169172 Ensembl | MGI Sequence Detail 6578 Not Applicable  
    polypeptide ENSMUSP00000129205 Ensembl | MGI Sequence Detail 893 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921563, MGI:1924592
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory