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Plekha7 Gene Detail
Summary
  • Symbol
    Plekha7
  • Name
    pleckstrin homology domain containing, family A member 7
  • Synonyms
    A430081P20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445094
    NCBI Gene: 233765
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:115722720-115907611 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 61.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5501 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445094
 protein coding gene Chr7:115722720-115907617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032889
 protein coding gene Chr7:119853728-120051638 (-)
A/J MGP_AJ_G0032872
 protein coding gene Chr7:116839782-117027409 (-)
AKR/J MGP_AKRJ_G0032804
 protein coding gene Chr7:119774982-119976183 (-)
BALB/cJ MGP_BALBcJ_G0032877
 protein coding gene Chr7:116549391-116767936 (-)
C3H/HeJ MGP_C3HHeJ_G0032587
 protein coding gene Chr7:119733686-119929358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033383
 protein coding gene Chr7:124652771-124852670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030355
 protein coding gene Chr7:118358791-118546635 (-)
CAST/EiJ MGP_CASTEiJ_G0031915
 protein coding gene Chr7:111421760-111621096 (-)
CBA/J MGP_CBAJ_G0032560
 protein coding gene Chr7:128778611-128988687 (-)
DBA/2J MGP_DBA2J_G0032712
 protein coding gene Chr7:114893283-115079663 (-)
FVB/NJ MGP_FVBNJ_G0032665
 protein coding gene Chr7:114738830-114931429 (-)
LP/J MGP_LPJ_G0032806
 protein coding gene Chr7:121334975-121535589 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032697
 protein coding gene Chr7:130395881-130599800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033403
 protein coding gene Chr7:118789405-118983684 (-)
PWK/PhJ MGP_PWKPhJ_G0031623
 protein coding gene Chr7:107767562-107957487 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031470
 protein coding gene Chr7:105506129-105724609 (-)
WSB/EiJ MGP_WSBEiJ_G0032028
 protein coding gene Chr7:119665230-119863057 (-)



Homology
more
  • Human Ortholog
    PLEKHA7, pleckstrin homology domain containing A7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHA7, pleckstrin homology domain containing A7
  • Links
    NCBI Gene ID: 144100
    neXtProt AC: NX_Q6IQ23
    UniProt: Q6IQ23

  • Chr Location
    11p15.2-p15.1; chr11:16777297-17014415 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show decreased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045659 Ensembl Gene Model | MGI Sequence Detail 184892 C57BL/6J ±  kb
transcript ENSMUST00000181998 Ensembl | MGI Sequence Detail 5149 Not Applicable  
polypeptide ENSMUSP00000138575 Ensembl | MGI Sequence Detail 1266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141928
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory