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Clspn Gene Detail
Summary
  • Symbol
    Clspn
  • Name
    claspin
  • Synonyms
    C85083, E130314M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445153
    NCBI Gene: 269582
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126450728-126487696 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 60.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1073 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445153
 protein coding gene Chr4:126450728-126488326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028783
 protein coding gene Chr4:128247092-128292411 (+)
A/J MGP_AJ_G0028742
 protein coding gene Chr4:123200349-123238965 (+)
AKR/J MGP_AKRJ_G0028695
 protein coding gene Chr4:126583136-126619115 (+)
BALB/cJ MGP_BALBcJ_G0028765
 protein coding gene Chr4:123772630-123809800 (+)
C3H/HeJ MGP_C3HHeJ_G0028479
 protein coding gene Chr4:126646114-126689011 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029207
 protein coding gene Chr4:133134935-133175567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026480
 protein coding gene Chr4:116330715-116367366 (+)
CAST/EiJ MGP_CASTEiJ_G0027912
 protein coding gene Chr4:124767487-124805006 (+)
CBA/J MGP_CBAJ_G0028445
 protein coding gene Chr4:136345472-136391549 (+)
DBA/2J MGP_DBA2J_G0028594
 protein coding gene Chr4:123648625-123685816 (+)
FVB/NJ MGP_FVBNJ_G0028561
 protein coding gene Chr4:122304452-122341294 (+)
LP/J MGP_LPJ_G0028695
 protein coding gene Chr4:128530968-128569425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028587
 protein coding gene Chr4:141377057-141417323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029245
 protein coding gene Chr4:126940599-126979646 (+)
PWK/PhJ MGP_PWKPhJ_G0027633
 protein coding gene Chr4:120142222-120179924 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027459
 protein coding gene Chr4:122771719-122817057 (+)
WSB/EiJ MGP_WSBEiJ_G0027992
 protein coding gene Chr4:127055584-127095884 (+)



Homology
more
  • Human Ortholog
    CLSPN, claspin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLSPN, claspin
  • Links
    NCBI Gene ID: 63967
    neXtProt AC: NX_Q9HAW4
    UniProt: Q9HAW4

  • Chr Location
    1p34.3; chr1:35720213-35769978 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show complete embryonic lethality during organogenesis. Heterozygous null mice exhibit reduced female fertility, develop lymphoid hyperplasia as they age, and show increased susceptibility to non-alcoholic fatty liver disease, and increased liver damage and tumorigenesis in the DEN model of hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    57
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042489 Ensembl Gene Model | MGI Sequence Detail 36969 C57BL/6J ±  kb
    transcript ENSMUST00000048391 Ensembl | MGI Sequence Detail 5027 Not Applicable  
    polypeptide ENSMUSP00000045344 Ensembl | MGI Sequence Detail 1315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140694
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory