About   Help   FAQ
Kcnh8 Gene Detail
Summary
  • Symbol
    Kcnh8
  • Name
    potassium voltage-gated channel, subfamily H (eag-related), member 8
  • Synonyms
    C130090D05Rik, ELK1, Kv12.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445160
    NCBI Gene: 211468
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:52909737-53286222 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 27.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12388 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445160
 protein coding gene Chr17:52909535-53286892 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023885
 protein coding gene Chr17:54129186-54517325 (+)
A/J MGP_AJ_G0023845
 protein coding gene Chr17:52617237-52998316 (+)
AKR/J MGP_AKRJ_G0023813
 protein coding gene Chr17:53235005-53627918 (+)
BALB/cJ MGP_BALBcJ_G0023847
 protein coding gene Chr17:52510376-52890083 (+)
C3H/HeJ MGP_C3HHeJ_G0023610
 protein coding gene Chr17:53937561-54333362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024291
 protein coding gene Chr17:56224312-56617765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021739
 protein coding gene Chr17:49285931-49638699 (+)
CAST/EiJ MGP_CASTEiJ_G0023092
 protein coding gene Chr17:54264526-54668788 (+)
CBA/J MGP_CBAJ_G0023586
 protein coding gene Chr17:58336959-58767882 (+)
DBA/2J MGP_DBA2J_G0023715
 protein coding gene Chr17:51388443-51768301 (+)
FVB/NJ MGP_FVBNJ_G0023681
 protein coding gene Chr17:51038271-51406323 (+)
LP/J MGP_LPJ_G0023795
 protein coding gene Chr17:54832420-55219135 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023709
 protein coding gene Chr17:57739051-58164073 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024336
 protein coding gene Chr17:53565357-53950586 (+)
PWK/PhJ MGP_PWKPhJ_G0022837
 protein coding gene Chr17:50850489-51235751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022651
 protein coding gene Chr17:50426802-50889943 (+)
WSB/EiJ MGP_WSBEiJ_G0023156
 protein coding gene Chr17:54181527-54570692 (+)



Homology
more
  • Human Ortholog
    KCNH8, potassium voltage-gated channel subfamily H member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNH8, potassium voltage-gated channel subfamily H member 8
  • Synonyms
    ELK, ELK1, elk3, hElk-1, Kv12.1
  • Links
    NCBI Gene ID: 131096
    neXtProt AC: NX_Q96L42
    UniProt: Q96L42

  • Chr Location
    3p24.3; chr3:19148510-19535642 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display loss of circadian patterns of neuron firing rates but no disruption of circadian rhythms of locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035580 Ensembl Gene Model | MGI Sequence Detail 376486 C57BL/6J ±  kb
    transcript ENSMUST00000039366 Ensembl | MGI Sequence Detail 4287 Not Applicable  
    polypeptide ENSMUSP00000049206 Ensembl | MGI Sequence Detail 1102 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory